New manuscript, led by @Mmcbuckner, in which I had a small role now on BioRxiv:
'Growth in a biofilm promotes conjugation of a blaNDM-1-bearing plasmid between Klebsiella pneumoniae strains'
https://www.biorxiv.org/content/10.1101/2023.01.05.522703v1
We show that growth in biofilm greatly increased the risk of conjugative transfer of a carbapenem resistance plasmid in K. pneumoniae without fitness costs and minimal transcriptional rearrangements.
Fully-Funded PhD Studentship available in my research team.
High-throughput approaches to develop novel therapies for the treatment of veterinary and clinical infections.
Essential reading for anyone studying bacterial pathogens:
Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019
"Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa—were responsible for 54·9% (52·9–56·9) of deaths among the investigated bacteria."
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02185-7/fulltext#%20
HT @onisillos
Looks like a super review!
"Molecular mechanisms of antibiotic resistance revisited"
https://buff.ly/3UW2LCS
In this Review, Blair, Webber and colleagues explore our understanding of the mechanisms of antibiotic resistance, including reduced permeability, antibiotic efflux, modification or alteration of the antibiotic target, modification or destruction of the drug itself, and bypass of metabolic pathways. They also discuss how this information can aid in developing the next generation of antimicrobial therapies.
Willem van Schaik
Professor Lesley Hoyles
Andrew Singer