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231 Following
39 Posts

We work on the #genetics of #immunity with particular interest in the determinants of response to #cancer #immunotherapy. We're based in the Department of #Oncology, University of #Oxford and our lab is at the MRC #WIMM

https://www.imm.ox.ac.uk/research/research-groups/genomics-of-inflammation-and-cancer-immunology
#equality #diversity #inclusivity #openscience

https://ishg2023.sciencesconf.org/ International symposium on Human Genomics Sept 20-22 2023 Paris France.
International Symposium on Human Genomics - Sciencesconf.org

@rlmcelreath
Old Nature letters are bonkers. I remember flipping through a collection of old Natures and randomly finding this 'stung by a bee?? Try cocaine!!!' letter

https://www.nature.com/articles/058435a0

Wasp and Bee Stings - Nature

As we are now in the thick of the wasp season, it may interest some of the readers of NATURE to know that cocaine is a remedy for wasp or bee stings. It acts apparently not only as a temporary local anæsthetic, but seems also to have the power of destroying the poison of the sting. I happened to have some 1/6th grain cocaine tabloids for hypodermic injection when a lady was badly stung by a wasp a year or two ago. Such stings have a great effect on her, not only producing a very large and painful swelling, but making her feel more or less unwell for two or three days. One tabloid dissolved in a few drops of water, and applied with the finger at once, almost removed the pain; a second, applied an hour or two after, completed the cure. A few days later I found the cocaine equally effective in the case of a young girl who had been severely stung. Since then I have kept a small bottle of a strong solution of cocaine ready for use, and it has always proved effective. It should, of course, be applied as soon as possible, but only two days ago I found that it gave great relief seven or eight hours after the sting.

Nature
@gpollara thank you!
We are recruiting a postdoctoral computational biologist to work on a large single cell RNAseq and immunogenetic analysis of determinants of response to Checkpoint Immunotherapy across several hundred individuals.
https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.display_form?p_company=10&p_internal_external=E&p_display_in_irish=N&p_process_type=&p_applicant_no=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y&p_recruitment_id=165255
Job Details

https://www.cell.com/immunity/fulltext/S1074-7613(23)00183-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761323001838%3Fshowall%3Dtrue

"antibody-secreting plasma cell (ASC) longevity past 60 days was independent of isotype but correlated with a phenotype that developed progressively and ultimately associated with an underlying "long-lived" ASC (LL ASC)-enriched transcriptional program"

#immunology #immunity

New work exploring innate immune activity on #DNA #methylation.

https://www.biorxiv.org/content/10.1101/2023.05.17.541041v1

We show LPS triggers highly punctual changes in methylation, with demethylation events profoundly enriched for enhancers. Notably, genes commonly mutated in #cancer form the target for demethylation. Further, we show exposure to LPS for 24h leads to epigenetic aging by 6 months on average. Finally, for the first time we describe genetic variation that modulates magnitude of immune methylation events.

New work exploring innate immune activity on #DNA #methylation.

https://www.biorxiv.org/content/10.1101/2023.05.17.541041v1

We show LPS triggers highly punctual changes in methylation, with demethylation events profoundly enriched for enhancers. Notably, genes commonly mutated in #cancer form the target for demethylation. Further, we show exposure to LPS for 24h leads to epigenetic aging by 6 months on average. Finally, for the first time we describe genetic variation that modulates magnitude of immune methylation events.

ggmagnify looks truly terrific

RT @olyerickson: Apologies if ‘ggmagnify’ has already been posted to #Rstats; its too cool to ignore! https://github.com/hughjonesd/ggmagnify

GitHub - hughjonesd/ggmagnify: Create a magnified inset of part of a ggplot object

Create a magnified inset of part of a ggplot object - GitHub - hughjonesd/ggmagnify: Create a magnified inset of part of a ggplot object

GitHub
Research software engineer vacancy to work with the widely used and growing @ExceedStudy @LeicesterBRC to Nov 2027, closing date 28 Feb 2023:
https://jobs.le.ac.uk/vacancies/6758/research-software-engineer.html
Research Software Engineer in Leicester | University of Leicester

View details and apply for this Research Software Engineer vacancy in Leicester. In this role you will develop, implement and support software and informatics approaches to manage the collection and assist with study management, integration of these data from diverse source...

University of Leicester
“Anti-intellectualism has been a constant thread winding its way through our political and cultural life, nurtured by the false notion that democracy means that ‘my ignorance is just as good as your knowledge.”
— Isaac Asimov, 1980.