@angusm @pluralistic I've never heard it described in exactly those terms, but yes there's a pretty good understanding in the US tech industry that when a startup transitions from being founder-led to outside-CEO-led, that it's a major transition and many don't thrive afterwards.
I don't think this is necessarily because the CEOs are incompetent, but because their priorities are not the founders' priorities. They generally are brought in by the company board (i.e. the investors) to ensure the investors get paid out, and to plan an "exit": typically either a sale to another company or an IPO.
Since cutting expenses is generally seen as the fastest way to profitability (this is practically doctrinal in US business schools), often the first thing they do is make cuts: to hiring, to workforce, to benefits. consolidating offices, etc. And that usually drives some of the better technologists (who can easily find other jobs) away for greener pastures, other startups, etc.