Time for another Research Retrospective! For #science ! This relatively recent paper is where we 'prove' (suggest) that you can predict where neutralizing antibodies will bind their antigens, by watching what happens when the antigen ( #COVID19 spike) binds it's target (human ACE2).

Using #massspec #HDX , when Spike binds ACE2, regions that aren't at the binding site change how they move... and that's where neutralizing #antibodies bind! #massspectrometry #biochemistry

https://pubs.acs.org/doi/full/10.1021/jasms.0c00465