Mascot Newsletter, March 2026:

Search BLIB spectral libraries with Mascot.

PET hydrolase expressed in fruit flies.

UK office has moved.

https://www.matrixscience.com/nl/202603/newsletter.html

#proteomics #massspec

matrixscience.com is being overwhelmed by millions of HTTP requests from distributed botnets, essentially a distributed denial of service (DDoS) attack. We are forced to mitigate it by restricting access to certain pages of dynamic content.

https://www.matrixscience.com/whats_new/mitigations-against-uncontrolled-web-crawlers-and-bots.html

#proteomics #massspec

Thunder-DDA-PASEF is an acquisition strategy for capturing more human leukocyte antigen (HLA) class I peptide ligands on Bruker timsTOF instruments. This month's blog shows how you can process Thunder-DDA-PASEF data with Mascot Distiller.

https://www.matrixscience.com/blog/processing-thunder-dda-pasef-data-with-mascot-distiller.html

#proteomics #massspec

Still looking for the right equipment for your #MassSpec research?

We offer a wide range of MS Consumables (e.g., spray emitters, nlc columns, ion sources), Services (e.g., filament repair) and Software Solutions (e.g., NIST, Wiley, SIMION, etc.).

Visit: https://www.mswil.com/

Using the blib2msp converter, Mascot Server can now search DDA spectral libraries in BLIB format. Here's an example for identifying mycobacteria.

https://www.matrixscience.com/blog/identifying-mycobacteria-with-custom-spectral-libraries.html

#proteomics #massspec

Tool of the week: Stop struggling with complex pipelines. 🧬

MdOA offers end-to-end metaproteomics directly in your browser. From raw MS/MS processing to clinical risk modeling—all with zero installation.

✅ Free for academic life scientists.
🚀 Analyze now: https://mdoa-tools.bi.denbi.de/home

#Metaproteomics #Bioinformatics #OpenScience #MassSpec

Mascot Newsletter, February 2026:

Strange software errors? Check your disk space.

Proteomic signatures in human fingertip regeneration.

Customise columns in the search log.

https://www.matrixscience.com/nl/202602/newsletter.html

#proteomics #massspec

Mascot Server can create and search NIST MSP formatted spectral libraries but not BLIB -- until now! We have developed an MSP to BLIB to MSP converter that allows Mascot Server to use BLIB libraries.

https://www.matrixscience.com/blog/converting-blib-spectral-libraries-to-msp-and-back-again-for-use-with-mascot-server.html

#proteomics #massspec

Mascot Newsletter, January 2026:

Ion intensity: peak area vs signal to noise?

Duplexing deuterated water-labeled samples for protein turnover rate estimation.

Role-based access with Mascot Security is useful in a variety of cases.

https://www.matrixscience.com/nl/202601/newsletter.html

#proteomics #massspec

Maximize your ESI sensitivity with CoAnn’s pulled and sharpened emitters.

The different emitter types offer flexibility to match various nanoLC columns and liquid infusion measurements in varieties of #MassSpec applications.

Learn more: https://www.mswil.com/nano-cap-micro-lc/spray-emitters/pulled-emitters/coann-pulled-emitters/