quantum computers can be networked now, more usable qubits will be able to be connected
more 'breakthroughs' will end up happening, things go slow at the start
#ibm #cleveland clinic #folding #enzymes #trypsin #catalysts #sims #merck index #buffer systems #chirality #nextplatform.com
The 1.75 Å resolution structure of the G. haemolysans M26 IgA1 protease trypsin-like domain is presented. The structural data suggest that the domain exists in an inactive pro-enzyme-like state when in the context of the full-length protein. This putative pro-enzyme may be activated after being N-terminally excised from the larger M26 enzyme structure through the potential stabilization of its S1 pocket and rearrangement of adjacent surface loops.
I use the #surfactant #SDC extensively for #proteomics sample prep. It is compatible with #Trypsin and easily removed. Very occasionally the solution will gel - and I can reverse this fortunately. Today I discovered why this happens:
https://doi.org/10.1021/jp409626s
"The results demonstrate that the gels are formed by intertwined fibrils, which are induced by enormous cycles of NaDC molecules driven by comprehensive noncovalent interactions, especially the hydrogen bonds."
gary
StructBiolCommunications
Brian Hampton