Science NewsAug 1, 2025
A new study reveals that lipid nanoparticle #stereochemistry impacts #mRNA drug delivery, with the (S,S) form of ALC315 showing similar efficacy but reduced toxicity, paving the way for improved mRNA therapies including personalized #cancer #vaccines.
https://nachrichten.idw-online.de/2025/08/01/shaping-the-future-of-mrna-based-drug-delivery
Shaping the future of mRNA based drug delivery

PLOS BiologyMay 21, 2025
Early in the #evolution of life a biochemical network was encapsulated within a membrane compartment. This study shows that specific #membrane forms can select for stereochemical compounds that match the pattern of #stereochemistry used by all known living things @PLOSBiology https://plos.io/4jdyLh1
Permeability selection of biologically relevant membranes matches the stereochemistry of life on Earth

Early in the evolution of life a biochemical network was encapsulated within a membrane compartment. This study shows that specific membrane forms can select for stereochemical compounds which match the pattern of stereochemistry used by all known living things.

carljbarFeb 16, 2025
What is the ethymology of the word stereochemistry? #ethymology #stereochemistry #chemistry
Show threadVictoria Stuart 🇨🇦 🏳️‍⚧️Dec 17, 2024

Mirror Bacteria Research Poses Significant Risks, Dozens of Scientists Warn
https://www.the-scientist.com/mirror-bacteria-research-poses-significant-risks-dozens-of-scientists-warn-72419
https://purl.stanford.edu/cv716pj4036
https://www.science.org/doi/10.1126/science.ads9158
https://news.ycombinator.com/item?id=42408361

* feasibility of creating mirror bacteria
* potentially serious/wide-ranging risks they could pose to humans, animals, plants, environment
* accompanies the Science Policy Forum article titled “Confronting risks of mirror life”,

#SyntheticBiology #MirrorLife #MirrorBacteria #biochemistry #stereochemistry #biopolymers

Mirror Bacteria Research Poses Significant Risks, Dozens of Scientists Warn

Synthetic biologists make artificial cells, but one particular kind isn’t worth the risk.

The Scientist Magazine®
Victoria Stuart 🇨🇦 🏳️‍⚧️Dec 17, 2024

Mirror life (mirror bacteria)
https://en.wikipedia.org/wiki/Mirror_life

* mirror-image life
* hypothetical form of life w. mirror-reflected molecular building blocks
* e.g. bacteria made of components that natural cells possess, but w. every biopolymer being of opp. stereochemistry

Comments:
* fascinating stuff; huge potential
* coincident w. my post re: synthetic media: https://mastodon.social/@persagen/113630612921903958
* here: synthetic biology

#SyntheticBiology #MirrorLife #MirrorBacteria #biochemistry #stereochemistry #biopolymers

Mirror life - Wikipedia

Getzler Lab at KenyonCollegeOct 26, 2024
#nyt #games needs an education in #polymer #stereochemistry
Lives in ChemistryAug 15, 2024
🎁HBT Jay S. Siegel who turns 65 today. At Princeton Univ. he developed a keen interest in #stereochemistry manifested in the co-authorship of the legendary JACS paper “La Coupe du Roi and its Relevance to Stereochemistry” (DOI: 10.1021/ja00344a003). Today he is Senior Advisor at the Univ. of Hong Kong. Aside from his stereochemistry expertise Jay is known for his #corannulene chemistry and for his contributions to #supramolecular science.
Knowledge ZoneJun 12, 2023

#KnowledgeByte: #Stereochemistry is the branch of chemistry concerned with the three-dimensional arrangement of atoms and molecules and the effect of this on chemical reactions.

One of it's most important application is drug design.

https://knowledgezone.co.in/posts/5d3d4b046982d1000c7af42e

What is Stereochemistry

The branch of chemistry concerned with the three-dimensional arrangement of atoms and molecules and the effect of this on chemical reactions.

Knowledge Zone
Scientific FrontlineNov 30, 2022
In this study, #AFIR is used to calculate #retrosynthetic, or reverse, reactions going from product #molecules to starting materials. Previously, AFIR has been used to predict small, simple reactions, but accurate #stereochemistry predictions were out of reach, limiting the technique’s applicability.
#Chemistry #sflorg
https://www.sflorg.com/2022/11/chm11302201.html
Automated chemical reaction prediction: now in stereo

Automated reaction path search method predicts accurate stereochemistry of pericyclic reactions using only target molecule structure.

Bruce FultonNov 18, 2022

"Pasteur not only made milk safe to drink, he established the germ theory of disease, saved the French silkworm population, confronted the scourges of anthrax and rabies, and transformed the curiosity of vaccination against smallpox into a general strategy for treating and preventing human diseases."

Pasteur ranks behind only Darwin among the most exceptional biological scientists of the 19th century."

#LouisPasteur #Pasteur #Microbiology #Stereochemistry
#Bicentennial

https://www.sciencenews.org/article/louis-pasteur-transformed-health-disease-microbiology

Louis Pasteur, born 200 years ago, transformed public health forever

Two centuries after his birth, Louis Pasteur's work on pasteurization, germ theory and vaccines is as relevant as ever.

Science News