It has taken a lot of effort by Abhipsa Sahu to complete her work on the Lcp enzyme family involved in Mycobacterial cell envelope synthesis, but it has resulted in a splendid article.
https://link.springer.com/article/10.1186/s12866-026-04722-4

#Microbiology #Mycobacteria #CellEnvelope #smegmatis

Impairment of two non-essential LytR-cpsA-psr (Lcp) cell wall ligases decelerate cell wall assembly in Mycolicibacterium smegmatis - BMC Microbiology

The LytR-CpsA-Psr (Lcp) family of proteins are highly abundant amongst actinomycetes and Gram-positive bacteria, and known to exist as multiple paralogs in

SpringerLink

Mechanism of #mycobacterial ATP synthase inhibition by #squaramides and second generation #diarylquinolines

High-resolution #cryoEM by John Rubinstein, Gautier Courbon et al reveals that binding of a candidate #tuberculosis drug and a different class of inhibitor to M. #smegmatis #ATPsynthase induces similar conformational changes

https://www.embopress.org/doi/full/10.15252/embj.2023113687