Mechanism of #mycobacterial ATP synthase inhibition by #squaramides and second generation #diarylquinolines

High-resolution #cryoEM by John Rubinstein, Gautier Courbon et al reveals that binding of a candidate #tuberculosis drug and a different class of inhibitor to M. #smegmatis #ATPsynthase induces similar conformational changes

https://www.embopress.org/doi/full/10.15252/embj.2023113687