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Mechanism of #mycobacterial ATP synthase inhibition by #squaramides and second generation #diarylquinolines

High-resolution #cryoEM by John Rubinstein, Gautier Courbon et al reveals that binding of a candidate #tuberculosis drug and a different class of inhibitor to M. #smegmatis #ATPsynthase induces similar conformational changes

https://www.embopress.org/doi/full/10.15252/embj.2023113687

Targeting ATP synthase with chromium (III) nutritional supplement for improved blood sugar control

A research team led by Professor Hongzhe Sun from the Department of Chemistry, Faculty of Science, The University of Hong Kong, has published a paper titled "Mitochondrial ATP synthase as a direct molecular target of chromium(III) to ameliorate hyperglycaemia stress" in Nature Communications.

4. "How does #ATPSynthase work? What would be a macroscopic analogy of it that one may encounter in our macroscopic world?"

Good response, and good choice of analogy. No complaints for #ChatGPT3 #GPT3.