After discussion about the state of my T1D and other concerns, my endo has me on Semiglutide to assist with insulin resistance and I'm going to be really curious to see how that goes.
I'm a few days in and I've already seen a major improvement in my time in range and while some of that is related to food intake/bolusing, there's other parts that are likely the CamAPS in conjunction with Semiglutide.
I definitely need to get my water station up and running again to make sure that I drink enough water during the day.
The thing I'm really noticing is that my eating and drinking habits are now more in line with how I ate as a teenager, before I had an illness that was prescribed a powerful antibiotic.
Now that I'm seeing how the food noise and random cravings have been turned way down, one of my goals while on this is to see about eating things that will encourage a diverse gut microbiome.
So far, though, my daily insulin requirements have halved and I haven't had a severe (under 60) or stubborn (lasting 1+ hour) low after taking Basti out for an evening walk. This makes me very happy for future stability while exercising, gardening, or other longer-duration activities.
My doc said that I'll probably see weight loss on this as well (sensible, as I'm fat), but we'll be dosing me based on what's best for addressing the insulin resistance, not aiming for weight loss as the goal.
In the past whenever I heard my mom, or anyone, say "ohhhh that meal was so big, ill be full all day, maybe into tomorrow"... I always rolled my eyes and just thought "You enjoy sleeping in that bed of lies".... But now that im on #Ozempic / #Semiglutide I can relate. I woke up today and had a huge hoagie for breakfast. But Now, 12 hours later, I dont even feel hungry. Hell some of it is still in my stomach i think (i taste it on my burps)... soooo weird.
The nice thing is i can eat a cheat meal now and it fills me for so long it isnt even really a cheat meal at all. Like yea it was too many calories for one meal, but over a whole day it was still on the low side.
As some of you know ive been on #Ozempic / #Wegovy / #Semiglutide once daily instead of the usual weekly.
I created a log of my historic blood accumulation when i was on once weekly and now that im on a daily adjusted dose. The blue lines show total amount in my blood, red i dicates equivelant weekly dose based on daily dose x7 and yellow is based on expected blood concentration.
As you can see the daily dosing produces much more constant levels. This is based on the typocal 7 day half life.
16 lbs down since started #Ozempic / #Semiglutide
I also started on TRT 3 days ago which seems to have jump started the weight loss again resulting in 2 more lbs lost since then.
Looks like I might also have hypothyroidism, waiting for the second test on that one.
Day three of dosing ozempic daily instead of weekly... Feeling much better about this so far.
Just for fun I decided to do the math to calculate the amount of Ozempic/semiglutide in my system based on the usualy dosing of every 7 days (in red), versus dosing every single day (at 1/7th) the dose (in green).
The two colors represent the upper and lower limit (it will at the upper limit right after a dose and at the lower limit right before a dose).
Notice that dosing every day makes for a much more stable concentration. Note this assumes a 1 mg dose (y-axis) and the x-axis is in days. I will start dosing every day tomorrow.
For those curious I also attached the equation that I calculated (derived) for the half-life. Both in its continuous form and as the summation.
The math around pharmakinetics of Ozempic/semiglutide (and many drugs in fact) is fun from a mathematics standpoint and not too hard to understand.
Basically it has a 7 day half life, so they dose it every 7 days. So each week the amount in your blood right after an injection is : 1, 1.5,1.75.... approaching 2. Which means after about a month you reach max dose and it naturally levels off. The curve is basically logarithmic if you did the math though.
Its a nice little intro to finite infinite series, a fun topic IMO.
For those who are curious, I started Ozempic / Semiglutide at the beginning of January, Ive lost 10 lbs since the start of it, 14 lbs since it "kicked in". Attached are two charts, one of my weight since starting taking it, the other my weight as measured since January 2017, just to add some perspective.
Stephan Hacker
Stephan Hacker
OtherRyn
🎓 Doc Freemo 
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