Fisk University student Cariuna Ellison's highlight features a Nature Communications publication from the laboratory of Crina Nimigean at Weill Cornell Medicine in which the authors describe the precise conditions and resulting mechanisms that result in thermosensitivity in a bacterium.
Read more here: https://medium.com/sbgrid-community-news/not-too-cold-just-right-19ebb647354e
In case you missed Jarrett Johnson's presentation on visualization and CryoEM in PyMOL in May, you can watch the recording on the SBGrid YouTube Channel.
More here: https://youtu.be/IxWcDX5nSgY
SBGrid's eLife paper received a citation in April from Antonina Roll-Mecak from the The National Institutes of Health in Journal of Cell Biology: Insights into retinal disease and non-tubulin glutamylation from a RPGR–TTLL5 complex structure.
New Title Alert: CryoBoltz- is a method for fitting atomic structures into cryo-EM density maps of dynamic proteins. It is built on top of Boltz-1, a state-of-the-art structure prediction model for biomolecular complexes.
Learn more here: https://cryoboltz.cs.princeton.edu/
SBGrid's eLife paper received a citation in April from Antonina Roll-Mecak from the The National Institutes of Health in Nature Structural and Molecular Biology: Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state.
Zehr et al. revealed the 2.7-Å cryo-electron microscopy reconstruction of human microtubules in situ in the axon of induced pluripotent stem cell (iPS cell)-derived neurons. It shows an expanded microtubule lattice yet bound to GDP, in contrast to the compacted lattice observed at the iPS cell stage.
New Title Alert: AlphaJudge- is a Python pipeline for evaluating AlphaFold2 and AlphaFold3 protein complex predictions by combining model confidence metrics such as ipTM, pTM, pLDDT, and PAE with interface-level biophysical descriptors including contacts, hydrogen bonds, salt bridges, buried area, solvation proxy, and shape complementarity.
Learn more here: https://github.com/KosinskiLab/AlphaJudge
SBGrid's eLife paper received a citation in April from Dirk Slotboom from University of Groningen in Nature Communications: Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters.
SbmA is a proton-driven transporter that imports antimicrobial peptides andstructurally resembles the transmembrane domain of ABC-transporters. Here, authors show through cryo-EM structures, EPR spectroscopy, and MD simulations that SbmA undergoes ABC-transporter-like conformational changes consistent with an alternating-access transport mechanism.
Technical Notes: April's software push includes updates to twelve titles -AlphaPulldown, Avogadro, BioEmu, ChemEx, ColabFold, CryoAtom, Foldtree, OpenFold3, PyMOL, Relion, Scipion, and TomoNet.
More here: https://sbgrid.org/software/recent/archive/2026/04/
New Title Alert: af_analysis- is a Python package for analysis of AlphaFold protein structure predictions from AlphaFold 2/3, ColabFold, AlphaFold-Multimer, AlphaPulldown, Boltz1, Chai-1, and MassiveFold.
Learn more here: https://github.com/samuelmurail/af_analysis/
Join our software webinar on May 12th to hear from Jarrett Johnson, Senior Developer from Schrödinger, on Upcoming improvements to visualization and CryoEM support in PyMOL.
Tuesday, May 12, 2026 - 12:00pm ET
Jarrett Johnson, Ph.D.
Senior Developer, Schrödinger, Inc.
Register here: https://sbgrid.org/webinars/
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