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HDC: Missed opportunities in diagnosis linked to middle-aged man’s death from rectal cancer
In January 2021, the man, who is only referred to as “Mr A” in a decision released today,…
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https://www.newsbeep.com/52802/
DWI comes out on top when comparing the accuracy of three state-of-the-art #MRI sequences in the detection of extramural venous invasion (EMVI) in locally advanced #rectal #cancer (LARC). (@f_crimi et al., @UniPadova) Filippo Crimì et al., University of Padova)
🔗 https://link.springer.com/article/10.1007/s00330-023-09655-4
Objectives The aim of this study was to determine the accuracy of three state-of-the-art MRI sequences for the detection of extramural venous invasion (EMVI) in locally advanced rectal cancer (LARC) patients after preoperative chemoradiotherapy (pCRT). Methods This retrospective study included 103 patients (median age 66 years old [43–84]) surgically treated with pCRT for LARC and submitted to preoperative contrast-enhanced pelvic MRI after pCRT. T2-weighted, DWI, and contrast-enhanced sequences were evaluated by two radiologists with expertise in abdominal imaging, blinded to clinical and histopathological data. Patients were scored according to the probability of EMVI presence on each sequence using a grading score ranging from 0 (no evidence of EMVI) to 4 (strong evidence of EMVI). Results from 0 to 2 were ranked as EMVI negative and from 3 to 4 as EMVI positive. ROC curves were drawn for each technique, using histopathological results as reference standard. Results T2-weighted, DWI, and contrast-enhanced sequences demonstrated an area under the ROC curve (AUC) respectively of 0.610 (95% CI: 0.509–0.704), 0.729 (95% CI: 0.633–0.812), and 0.624 (95% CI: 0.523–0.718). The AUC of DWI sequence was significantly higher than that of T2-weighted (p = 0.0494) and contrast-enhanced (p = 0.0315) sequences. Conclusions DWI is more accurate than T2-weighted and contrast-enhanced sequences for the identification of EMVI following pCRT in LARC patients. Clinical relevance statement MRI protocol for restaging locally advanced rectal cancer after preoperative chemoradiotherapy should routinely include DWI due to its higher accuracy for the diagnosis of extramural venous invasion compared to high-resolution T2-weighted and contrast-enhanced T1-weighted sequences. Key Points • MRI has a moderately high accuracy for the diagnosis of extramural venous invasion in locally advanced rectal cancer after preoperative chemoradiotherapy. • DWI is more accurate than T2-weighted and contrast-enhanced T1-weighted sequences in the detection of extramural venous invasion after preoperative chemoradiotherapy of locally advanced rectal cancer. • DWI should be routinely included in the MRI protocol for restaging locally advanced rectal cancer after preoperative chemoradiotherapy.
HineyMan
News Beep
Your Autistic Life FR/EN/ES
Seán Fenian
Howard Smith MD, AM
European Radiology