Emergent biosynthetic pathway to essential amino acids by metabolic metathesis
https://www.biorxiv.org/content/10.1101/2023.09.06.556532v1?rss=1

* alkene metathesis unknown in extant biochemistry
* alkenic amino acid vinylglycine can be generated in biocompatible reaction
* vinylglycine produced in situ then used as precursor of isoleucine & methionine
* allows growth of Escherichia coli strains normally requiring these essential amino acids

#biochemistry #MolecularBiology #SyntheticBiology #DirectedEvolution #auxotrophy #prototrophy