Mastodawn

Big news! I was on a podcast for @bcchresearch.bsky.social
This was research in #preterm #brains, #oxygenation measured with #arterialspinlabelling and #qsm, and looking at ventilation methods.

Read more about the study here: https://bsky.app/profile/weberam2.bsky.social/post/3lpn2srfgmk2q

https://plmlex.clicks.mlsend.com/tl/c/eyJ2Ijoie1wiYVwiOjQ4Nzk1MSxcImxcIjoxNjU4MzQxOTU3NDE5Njc3OTQsXCJyXCI6MTY1ODM0MjA5NDc3MjY0NTgxfSIsInMiOiI1NzhjYjMwN2ZhYjM1ZGM2In0

Alexander Mark Weber (@weberam2.bsky.social)

🚨NEW PAPER OUT IN #NMRinBiomedicine🚨 We developed a noninvasive MRI method to measure brain oxygen use (CMRO₂) and blood flow (CBF) in preterm infants. This could be key for understanding early brain development! #Neonatology #MRI #BrainHealth #openaccess 👶🧪 https://doi.org/10.1002/nbm.70065 🧵 1/9

Bluesky Social

Stefan Johansson, MD PhD May 21, 2025

This paper on #furosemide treatment of #preterm infants is a great RCT, but I think there is a common misunderstanding, from reading comments like "Yes, I know furo is not working!".
The RCT was done to look into furosemide safety, not efficacy.
I am also sceptical about furosemide and BPD prevention, would be too good to be true, but we would need a much larger trial to look into that question.

https://pubmed.ncbi.nlm.nih.gov/40306549/

#NeoMastodon

Furosemide Safety in Preterm Infants at Risk for Bronchopulmonary Dysplasia: A Randomized Clinical Trial - PubMed

GOV: NCT02527798.

PubMed

MEActNOW Mar 23, 2025

👩🏼‍🔬ℹ️ New methodology developed at Yale School of Medicine (YSM), combined with techniques that analyze multiple types of molecular information, is allowing researchers to more safely gain insight into the immune systems of extremely #preterm babies. Learn more 👇🏼

Alexander Weber Mar 20, 2025

🚨NEW PAPER OUT IN #PEDIATRICRESEARCH🚨
We used quantitative susceptibility mapping (#QSM) to measure cerebral oxygenation in #preterm #neonates 🧠💡 We explored whether isolating paramagnetic components improved the accuracy in major cerebral veins.
https://www.nature.com/articles/s41390-025-03966-6
#openaccess #mri
🧵 1/3

The application of magnetic susceptibility separation for measuring cerebral oxygenation in preterm neonates - Pediatric Research

Quantitative susceptibility mapping (QSM), a magnetic resonance imaging (MRI) modality sensitive to deoxyhemoglobin, is a promising method for measuring cerebral oxygenation in human neonates. Paramagnetic sources, like deoxyhemoglobin, however, can be obscured by diamagnetic sources such as water and myelin. This study evaluated whether QSM images, or isolated paramagnetic components, are more accurate for measuring oxygenation of cerebral veins of preterm neonates, and explored oxygenation differences between the major cerebral veins. 19 preterm neonates were scanned on at term equivalent age on a 3T MRI using a multi-echo susceptibility-weighted imaging sequence. Susceptibility values were calculated from QSM images to determine oxygen saturation (SvO2) in the superior sagittal sinus (SSS) and central cerebral veins (CCV). The paramagnetic components of QSM images were isolated, and SvO2 values were recalculated. The mean SvO2 values from QSM were 72.4% (SD, 3.4%) for the SSS and 68.7% (SD, 3.5%) for the CCV. SvO2 values for paramagnetic components were 58.1% (SD, 7.3%) for the SSS and 57.7% (SD, 7.0%) for the CCV. While paramagnetic component decomposition yielded SSS values closer to those found in the literature, it increased variability. No significant oxygenation differences were found between the SSS and CCV, contrasting with prior studies.

Nature

The Incubator Podcast Feb 3, 2025

Want to stay up to date with the most recent evidence in neonatology? The latest Journal Club episode on The Incubator Podcast dives into the newest research, breaking down key findings and their impact on neonatal care.

🎧 Tune in for expert insights and analysis on the latest studies shaping the field. Don’t miss out!

📢 Listen now on your favorite podcast platform!
🔗 https://buff.ly/42C868V

#Neonatology #NICU #Research #Preterm #Babies #TheIncubator #Podcast #Medical

#273 - 📑 Journal Club - The Complete Episode from January 19th 2024

Hello Friends 👋In this week’s Journal Club, Ben and Daphna discuss six impactful studies shaping neonatal care. The conversation opens with a retrospective study exploring the timeline and factors influencing liberation from respiratory support in infants with severe bronchopulmonary dysplasia (BPD), offering valuable insights for parental counseling and care planning. A survey on enteral nutrition practices in U.S. NICUs highlights variability in feeding protocols and fortification strategies,

The Incubator

The Incubator Podcast Feb 2, 2025

Want to stay up to date with the most recent evidence in neonatology? The latest Journal Club episode on The Incubator Podcast dives into the newest research, breaking down key findings and their impact on neonatal care.

🎧 Tune in for expert insights and analysis on the latest studies shaping the field. Don’t miss out!

📢 Listen now on your favorite podcast platform!
🔗 https://buff.ly/42C868V

#Neonatology #NICU #Research #Preterm #Babies #TheIncubator #Podcast #Medical

#273 - 📑 Journal Club - The Complete Episode from January 19th 2024

Hello Friends 👋In this week’s Journal Club, Ben and Daphna discuss six impactful studies shaping neonatal care. The conversation opens with a retrospective study exploring the timeline and factors influencing liberation from respiratory support in infants with severe bronchopulmonary dysplasia (BPD), offering valuable insights for parental counseling and care planning. A survey on enteral nutrition practices in U.S. NICUs highlights variability in feeding protocols and fortification strategies,

The Incubator

The Incubator Podcast Feb 1, 2025

Want to stay up to date with the most recent evidence in neonatology? The latest Journal Club episode on The Incubator Podcast dives into the newest research, breaking down key findings and their impact on neonatal care.

🎧 Tune in for expert insights and analysis on the latest studies shaping the field. Don’t miss out!

📢 Listen now on your favorite podcast platform!
🔗 https://buff.ly/42C868V

#Neonatology #NICU #Research #Preterm #Babies #TheIncubator #Podcast #Medical

#273 - 📑 Journal Club - The Complete Episode from January 19th 2024

Hello Friends 👋In this week’s Journal Club, Ben and Daphna discuss six impactful studies shaping neonatal care. The conversation opens with a retrospective study exploring the timeline and factors influencing liberation from respiratory support in infants with severe bronchopulmonary dysplasia (BPD), offering valuable insights for parental counseling and care planning. A survey on enteral nutrition practices in U.S. NICUs highlights variability in feeding protocols and fortification strategies,

The Incubator

Alexander Weber Dec 5, 2024

🚨NEW PAPER OUT IN #PLOSCOMPLEXSYSTEMS🚨

#hurst exponent of fMRI 🧲 data from #preterm 👶 at #sickkids

we explored how the brains of babies born earlier than normal develop up until the time when most babies are born
https://journals.plos.org/complexsystems/article?id=10.1371/journal.pcsy.0000024
#openaccess #mri #neuroscience #pediatrics
🧵

Long-range temporal correlation development in resting-state fMRI signal in preterm infants: Scanned shortly after birth and at term-equivalent age

Author summary In our study, we explored how the brains of babies born earlier than normal develop up until the time when most babies are born. We used a special technique that examines the complexity of the functional activity of different regions of the brain. What we discovered was that starting shortly after birth, the measure of complexity was more random than ordered. However, as the babies got older, all areas of their brain showed functional activity that became more ordered. Moreover, it appears that some areas of the brain, such as those responsible for moving and seeing, became more ordered faster than other areas, such as ones located in the frontal area of the brain. This insight into how brains develop in the early weeks of life, from more random to more ordered, and in some regions more than others, may help inform neuroscientists and clinicians about what is happening to the brain in the earliest stages of life outside the womb.

prabirkc Sep 14, 2024

Preterm infants (<34 weeks’ gestation), critically ill infants with AKI, and infants with critical cardiac disease are at-risk of CKD following NICU discharge. We recommend all at-risk infants have a discharge kidney health evaluation that includes a properly obtained blood pressure (BP), serum creatinine level, and kidney health education in preparation for hospital discharge. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2823652 #MedMastodon #Preterm #Preemie #Newborn

Kidney Health Monitoring in Neonatal Intensive Care Unit Graduates

This consensus study presents recommendations from a 51-member working group regarding kidney follow-up care for infants discharged from the neonatal intensive care unit.