CharrveinJan 30, 2025

PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish

Marie Raynaud, etal.

Brilliant study and fascinating biology

#Rapid #Evolution of the #prdm9 genes, and the hotspots
#salmonid #qtl #genetics #wgd @PLOSBiology

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002950

PRDM9 drives the location and rapid evolution of recombination hotspots in salmonid fish

PRDM9 is a DNA-binding protein that helps determine the location of recombination hotspots in many mammals. This study of several species of salmonid fish reveals that PRDM9 function is conserved across vertebrates and that the peculiar evolutionary runaway caused by PRDM9 has been active for several hundred million years.

PLOS BiologyJan 8, 2025
PRDM9 helps determine the location of recombination hotspots in many mammals. Study of salmonid fish reveals that #PRDM9 function is conserved across vertebrates, and this peculiar evolutionary runaway caused by PRDM9 has been active for 100s of millions of years #plosbiology plos.io/3DIvFCG
Julien JOSEPHNov 20, 2023

I am very pleased to share with the mastodon community the first part of my PhD work:

High prevalence of Prdm9-independent recombination hotspots in placental #mammals

https://www.biorxiv.org/content/10.1101/2023.11.17.567540v1

This work was done in collaboration with @djivanprentout Alexandre Laverré, Théo Tricou and @duret_lbbe. (1/8)

#Recombination #PopGen #Evolution #gBGC #PRDM9

Julien JOSEPHNov 7, 2022

#introduction
I'm a PhD student based in Lyon (France) with broad interests in molecular evolution.
My three main axes of research are 1) fitness landscapes, DFE estimation and adaptation, 2) GC-biased gene conversion, mutational biases and genetic load, and 3) recombination landscapes and the evolution of the protein PRDM9.

#Selection #Adaptation #gBGC #Recombination #PRDM9