Show threadJulien JOSEPHNov 20, 2023
As linkage disequilibrium maps are costly to build for a large number of species, we used another proxy for recombination rate that rely on the signature left in base composition by recombination-associated gene conversion events (GC-biased gene conversion #gBGC). This proxy is based on the equilibrium GC content, i.e. the GC content that the sequence would reach if the substitution patterns occurring in a branch were to continue for a long period of time. (3/8)
Julien JOSEPHNov 20, 2023

I am very pleased to share with the mastodon community the first part of my PhD work:

High prevalence of Prdm9-independent recombination hotspots in placental #mammals

https://www.biorxiv.org/content/10.1101/2023.11.17.567540v1

This work was done in collaboration with @djivanprentout Alexandre Laverré, Théo Tricou and @duret_lbbe. (1/8)

#Recombination #PopGen #Evolution #gBGC #PRDM9

Julien JOSEPHNov 7, 2022

#introduction
I'm a PhD student based in Lyon (France) with broad interests in molecular evolution.
My three main axes of research are 1) fitness landscapes, DFE estimation and adaptation, 2) GC-biased gene conversion, mutational biases and genetic load, and 3) recombination landscapes and the evolution of the protein PRDM9.

#Selection #Adaptation #gBGC #Recombination #PRDM9