katch wreck`Here, we show that the nascent polypeptide-associated complex controls the cotranslational modification of histones H2A and H4 by recruiting NatD and the upstream enzyme MetAP1 to ribosomes. MetAP1 and NatD cooperate on the ribosome to create a confined environment for the efficient sequential modification of the nascent histone chain.`
StructBiolCommunicationsHow iron helps collagen enzymes work - and what happens when it doesn’t #PostTranslationalModifications #DNAViruses #Dioxygenases https://doi.org/10.1107/S2053230X25003735
Husnain🧠 Exciting News! Our review article is published!
We explore how miRNAs could enhance diagnostics and their role in PTM and Aging 🧠🧬
🔗https://doi.org/10.3389/fnmol.2024.1386735
🔗 https://go.nature.com/3FSQrke
#MicroRNA #Neurodegeneration #PostTranslationalModifications #AgingAndDisease #MolecularNeuroscience #RNARegulation #GeneExpression #Biomarkers #EarlyDiagnosis #FrontiersInNeuroscience #ScientificResearch #BTU #Charite #DZNE #BrainHealth #Epigenetics #NextGenDiagnostics #Neurobiology #miRNABasedDiagnostics
StructuralBiologyThe role of post-translational modifications in influencing protein structure and function, and the frequency and representation of these modifications in the PDB, are examined #PostTranslationalModifications #ProteinDataBank #Glycosylation t.co/iocwcaTdCy
Amelia Cervera 🧬A viral ADP-ribosyltransferase attaches RNA chains to host proteins (2023).
#Virus #Phage #PostTranslationalModifications
A viral ADP-ribosyltransferase attaches RNA chains to host proteins - Nature
Bacteriophage T4 uses an enzyme known as ADP-ribosyltransferase ModB to modify the translational apparatus of bacteria it infects, not only by ADP-ribosylating proteins, but also by attaching entire RNA chains in a process known as RNAylation.