David Ojcius4d ago

Discovery of human gut #phage -encoded anti-CRISPR proteins unveils diverse mechanisms for phages to evade type II #CRISPR immunity.

Gut #phages encode diverse Acrs; 651 candidates found, including some with dual regulatory & CRISPR‑inhibitory roles.

https://davidojcius.blogspot.com/2026/03/discovery-of-human-gut-phage-encoded.html

#microbioloy

David OjciusFeb 27

Phage P100 resistance in clinical & foodborne Listeria monocytogenes isolates is associated with adsorption-inhibiting mutations & fitness trade-offs.

Study shows diverse P100 resistance mechanisms in #Listeria & significant serovar‑dependent fitness costs.

https://davidojcius.blogspot.com/2026/02/phage-p100-resistance-in-clinical-and.html #OpenAccess #bacteriophage #phage #food

David OjciusFeb 7

Molecular basis for anti-jumbo phage #immunity by AVAST type 5.

Avs5 detects an early jumbo‑phage activator and halts infection by rapidly hydrolyzing NAD+.

https://www.sciencedirect.com/science/article/pii/S1097276526000249 #phage #bacteriophage #microbiology

RaurquizFeb 6
#otd #startrek #voyager #Phage #janeway #chakotay #tuvok #kim #paris #belannatorres #kes #emh #neelix #dereth #motura #seska #Vidiians #startrek59 @trekcore
 Hacker NewsJan 31
Show HN: Phage Explorer
https://phage-explorer.org/
#ycombinator #phage #bacteriophage #bioinformatics #genome_visualization #DNA_sequence #amino_acid #lambda_phage #virology #microbiology
Phage Explorer — Bacteriophage Genome Visualization

Visualize and analyze bacteriophage genomes with color-coded DNA/amino acid sequences, 3D structures, and 40+ analysis tools. Free, open-source, works offline.

Phage Explorer
TrueInfectionsDec 18

"The very discovery of phage was the subject of a prolonged dispute between two camps: on one side was Félix d’Herelle,Citation5 the French-Canadian autodidact who first recognize ..."

https://www.tandfonline.com/doi/full/10.4161/bact.20757

#InfectiousDisease #Medicine #phage

Prof Paula SalgadoNov 12
A pleasure to have @mfwhite2.bsky.social for our first #BiosciencesInstitute seminar this year and hearing all about #bacterial #phage defences
Benjamin Carr, Ph.D. 👨🏻‍💻🧬Oct 30
#AI can now design functional #viruses - not the computer kind, either
Inject this synthetic #phage into #Ecoli and it kills better than the real thing
#Bacteriophages, are viruses that infect bacteria, have been widely studied since their discovery in the early 20th century. The end result of the AI portion of the project was a pool of 302 candidate #genomes, 285 of which were able to generate full genomes. Of those, 16 were found to inhibit growth of E. coli #bacteria.
https://www.theregister.com/2025/09/18/researchers_just_created_a_working/
AI can now design functional viruses – not the computer kind, either

: Inject this synthetic phage into E. coli and it kills better than the real thing

The Register
TheNudeSurrealistOct 8

1/5

Today I finished reading the non-fiction book The Good Virus, by Tom Ireland. Picked it up somewhat at random since I don't usually read non-fiction, and I'm not usually into biology.

But it turned out to be an excellent book, perhaps the best book I've read this year.

https://www.amazon.com/Good-Virus-Amazing-Forgotten-Promise-ebook/dp/B0BHPRSWFT/

#bookreview #bookstodon #phage

Amazon.com

katch wreckSep 25

"Entelli-02 exhibits 88% host coverage against The Alfred Hospital’s ECC isolate collection (n = 206), confirmed by plaque formation and reduced bacterial load in septicaemic mice by >99%. We produced this cocktail as a therapeutic-grade product, ready for clinical use. Entelli-02 represents a hospital-specific phage cocktail with frontline efficacy and on-demand availability."

https://www.nature.com/articles/s41564-025-02130-4

#phage

Rational design of a hospital-specific phage cocktail to treat Enterobacter cloacae complex infections - Nature Microbiology

The Entelli-02 phage product containing five phages has frontline potential to address infections caused by the multidrug-resistant Enterobacter cloacae complex.

Nature