My postdoc work at Isaac Bianco's lab is finally out on @eLife !
https://elifesciences.org/articles/78381

Combining #lightsheet volumetric functional imaging and a spiking network simulation, we were able to show that a simple connectivity motif in the #zebrafish #optictectum explains multiple features in ongoing population dynamics, their impact on trial-to-trial variability, and trends in experience dependent behavior.

It is a neat example of how #networkdynamics can explain why neuronal and behavioural responses vary, or how past activity sets the ever-changing background for new input (that, in turn, will make its own long-lasting splash)

Sierra Dixon, Bailey Calder &co show that valproic acid exposure leads to a delay in #zebrafish optic tectum #neurogenesis and #neuron specification:

https://journals.biologists.com/bio/article/12/1/bio059567/286805/Valproic-acid-affects-neurogenesis-during-early

“Overall, our findings provide an initial characterisation of the deviances in development of the optic tectum in an Autism model”

Check out this interview with co-first author Bailey to find out more:

https://journals.biologists.com/bio/article/12/1/bio059820/286698/First-person-Bailey-Calder

#OpticTectum #Axonogenesis #Dendritogenesis #Science #BiologyOpen #Biology #DevBio