Biology OpenSierra Dixon, Bailey Calder &co show that valproic acid exposure leads to a delay in #zebrafish optic tectum #neurogenesis and #neuron specification:
“Overall, our findings provide an initial characterisation of the deviances in development of the optic tectum in an Autism model”
Check out this interview with co-first author Bailey to find out more:
https://journals.biologists.com/bio/article/12/1/bio059820/286698/First-person-Bailey-Calder
#OpticTectum #Axonogenesis #Dendritogenesis #Science #BiologyOpen #Biology #DevBio
Valproic acid affects neurogenesis during early optic tectum development in zebrafish
Summary: Optic tectum (OT) is a midbrain structure that is important in integrating multimodal input and guides non-voluntary movements in response to prevalent stimuli. Here we show that valproic acid, associated with autism spectrum disorder, leads to a delay in OT's neurogenesis and neuron specification.