PLOS BiologySep 11, 2025
#Morphogens cooperate to guide development of the #cochlea. This Primer explores a @PLOSBiology study showing how #PlanarCellPolarity of individual cells is integrated across distinct regional compartments to ensure proper organ #morphogenesis. Paper: https://plos.io/4nmD8IW Primer: https://plos.io/3IjPkLR
preLightsJul 20, 2023

How do morphogen signals instruct stem cells to acquire a specific neuronal identity? A #preprint by Neal Amin, Kevin Kelley and team provides us with a roadmap. 🧫 🛣️ 🧠

Great new #preLight from Monica Tambalo which includes a response from the authors...👀

#preLight 👉 https://prelights.biologists.com/highlights/generating-human-neural-diversity-with-a-multiplexed-morphogen-screen-in-organoids/

#morphogens #organoids #StemCells #neuroscience

Generating human neural diversity with a multiplexed morphogen screen in organoids - preLights

How do morphogen signals instruct stem cells to acquire a specific neuronal identity? This preprint by Amin, Kelley, and team provides us with a roadmap. 🧫 🛣️ 🧠

preLights
Victoria Stuart 🇨🇦 🏳️‍⚧️Jul 11, 2023

Emergent digital bio-computation through spatial diffusion & engineered bacteria
https://www.biorxiv.org/content/10.1101/2023.07.07.548081v1?rss=1

Our computers are composed of bacterial colonies which receive information in the form of diffusible morphogen-like signals.

A computation is encoded by the physical locations of the input morphogen & the output receiver colonies.

These computational bacterial communities will help explore information processing in biological systems.

#SyntheticBiology #biocomputation #morphogens

Julien DelpierreNov 13, 2022
"[...] varying the duration of #BMP #signaling leads to either pluripotent, mesodermal, and extraembryonic states, while varying the concentration does not cause efficient mesodermal differentiation at any dose [...] appropriately timed pulse of BMP induces #hPSCs to a mesodermal fate more efficiently that sustained signaling at any concentration. [...] this effect is due to a combinatorial interpretation of the applied BMP signal and induced endogenous #Wnt signaling."
https://www.biorxiv.org/content/10.1101/2022.11.11.516212v1?rss=1
#DevBio #CellFate #GermLayers #morphogens #Differentiation