John Vaccaro (johniac)May 5, 2025

SciTech Chronicles. . . . .May 5th, 2025

https://bit.ly/stc050525

#neurodegenerative #tau #misfolded #fibrils #nova #TCrB #Red #White #modular #Unitree #"B2 quadruped" #"extreme environment" #"water Cannon" #imaging #D-PSCAN #NTS #VNS #mtDNA #mutant #Disease #heteroplasmy

SciTech Chronicles. . . . . . . . .May 5th, 2025

This summer I hear the drumming Vol II No 29 242 links Curated Mission Control RSS Feed Wordpress SubStack Comments Buy Me A Coffee Synth...

PLOS BiologyApr 10, 2025
TMED9 mediates export of misfolded #prion proteins from the ER. This study shows that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @PLOSBiology https://plos.io/44kURu5
TMED9 coordinates the clearance of misfolded GPI-anchored proteins out of the ER and into the Golgi

The p24-family member TMED9 mediates export of misfolded prion proteins from the ER. Here, the authors show that TMED9 has a new role in capturing misfolded GPI-anchored proteins that are released by calnexin within the ER and moved into the Golgi for subsequent degradation via the RESET pathway.

Scientific FrontlineFeb 2, 2023
Many #neurological disorders arise from damage to #brain #cells due to a build-up of #misfolded or aggregated #proteins in the brain, like the tau protein and the #amyloid-beta protein.
#Alzheimer #Neuroscience #Biology #sflorg
https://www.sflorg.com/2023/02/ns02022301.html
HudsonAlpha scientists make new discovery linked to Alzheimer’s disease

Alterations to the DNA code itself are only one of the ways that protein production can go awry