26-Sep-2025
What is the significance of the evolution from #chiral molecular #macrocycles to chiral topological macrocycles?

https://www.eurekalert.org/news-releases/1099922

#science #chemistry #selfAssembly #nanoworld #macromolecules '#supramolecularChemistry #chirality

Mirror-Image Cyclodextrins

Separation of enantiomeric cyclodextrins achieved

https://www.chemistryviews.org/mirror-image-cyclodextrins/

#cyclodextrins #macrocycles #chemistry #chemistryviews #chemviews

📢 Invitation to submit!

New thematic issue “Novel #macrocycles: from synthesis to #supramolecular function” edited by Prof. Pablo Ballester, Konrad Tiefenbacher, Carmine Gaeta, Carmen Talotta, Margherita De Rosa and Paolo Della Sala in the Beilstein Journal of Organic Chemistry:
➡️ https://www.beilstein-journals.org/bjoc/series/142?M=y

Submission deadline 📅 March 31, 2025

#SupramolecularChemistry #catalysis #mechanomolecules #BJOC 💎🔓

Cyclic Hexamer of Naphthylene Synthesized:
Cobalt-mediated oxidation of 2,2′-dilithio-1,1′-binaphthyl by ferrocenium salts gives [6]cyclo-1,2-naphthylene

https://www.chemistryviews.org/cyclic-hexamer-of-naphthylene-synthesized/

#macrocycles #cpp #orgchem #chemistry #chemistryviews #chemviews

Aza-Superbenzene and Aza-Supernaphthalene

Dications, tetracations, and hexacations of a tetraazasuperbenzene and a hexaazasupernaphthalene show global aromaticity or anti-aromaticity

https://www.chemistryviews.org/aza-superbenzene-and-aza-supernaphthalene/

#macrocycles #superbenzene #aromaticity #antiaromaticity #science #chemistry #chemistryviews

David Baker has made a name for himself by applying computer science concepts to #biology: #AlphaFold competitor RoseTTAFold, de novo AI protein design

This time, it's not proteins, but a class of drugs called #macrocycles on the receiving end of his team's efforts

by me for @STAT
https://www.statnews.com/2024/04/25/after-ai-protein-folding-david-bakers-lab-identifies-millions-of-smaller-drug-candidates/

#AI #protein #pharma #drugdiscovery #science #research #AcademicMastodon

Fun use of macrocycles as property modifiers in polymer chemistry with a explanation for the fall-off at higher concentrations. Just wish the impact had been bigger - it's big synthetic effort for relatively small payoffs in modulus.

#chemistry #chemiverse #macrocycles #cyclicpolymers #LaPoSmaPo

https://pubs.acs.org/doi/10.1021/acs.macromol.3c00148

Palladium-Catalyzed Reactions Give Higher Pyrenylenes: Pyrene-based o-trimethylsilyl triflates used to prepare pyrenylenes with up to ten-membered rings
https://www.chemistryviews.org/palladium-catalyzed-reactions-give-higher-pyrenylenes/

#science #chemistry #PAHs #macrocycles #arynes #chemistryviews