Carbohydrate produced by bacteria triggers marine biofouling
Most bottom-dwelling marine invertebrate animals, such as sponges, corals, worms and oysters, produce tiny larvae that swim in the ocean prior to attaching to the seafloor and transforming into juveniles. A previous study led by researchers at the University of Hawai'i (UH) at Mānoa School of Ocean and Earth Science and Technology (SOEST) unlocked the mystery of how the floating larvae responsible for establishing marine biofouling settle and metamorphose: specific bacteria in biofilms are a signal that they have found the "right spot."
Researchers uncover details of how bacteria build protective barriers, may inform new antibiotics
Yale researchers have uncovered new details on how bacteria like E. coli build their protective barriers, which will inform new antibiotic development.
The new #antibiotic #Zosurabalpin traps a substrate-bound conformation of the #lipopolysaccharide (LPS) transporter #Lpt by recognizing a composite binding site made up of both Lpt and its substrate. #LPS
https://www.nature.com/articles/s41586-023-06799-7
A new antibiotic traps lipopolysaccharide in its intermembrane transporter - Nature
A mechanism of lipid transport inhibition has been identified for a class of peptide antibiotics effective against resistant Acinetobacter strains, which may have applications in the inhibition of other Gram-negative pathogens.
Scientists hail new antibiotic that can kill drug-resistant bacteria
Zosurabalpin has defeated strains of pneumonia and sepsis in mice, raising hopes for human trials
CellBioNews
Boris Tefsen
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