PLOS BiologyMar 19
#Fungi adapt to temperature during host invasion, but how is this controlled? This study shows that an HDAC-dependent chromatin program enables thermal dimorphism by coordinating activation of pathogenic growth & repression of filamentation in #Histoplasma @PLOSBiology https://plos.io/40D0f9a
The Rpd3 histone deacetylase is a critical regulator of temperature-mediated morphogenesis and virulence in the human fungal pathogen Histoplasma

Fungi adapt to temperature during host invasion, but how this response is controlled is not well understood. This study shows that a histone deacetylase-dependent chromatin program enables thermal dimorphism by coordinating activation of pathogenic growth and repression of filamentation in Histoplasma.

Jason StajichNov 29, 2022
https://www.smithsonianmag.com/smart-news/fungi-that-cause-lung-infections-may-be-spreading-across-the-us-180981189/ #fungi #coccidioides #blastomyces #histoplasma #thinkfungi
Fungi That Cause Lung Infections May Be Spreading Across the U.S.

Doctors are likely to misdiagnose cases due to outdated maps of these fungi’s ranges

Smithsonian Magazine