Chordate Medicals studie utvecklas väl, utvidgar med Schweiz
Chordate rapporterar att PM010-studien utvecklas väl och lägger därför till en 12:e studieklinik till eftermarknadsstudien för migränbehandling då Inselspital, Universitätsklinik für Neurologie, i Bern har fått etiskt godkännande att gå med i studien. Klinikens prövningsledare i studien är Prof. Dr. Christoph Schankin, en betydelsefull opinionsbildare både nationellt och internationellt. – PM010-studien utvecklas väl med i […]
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Scientist Accidentally Discovers The Oldest Brain of Any Vertebrate
Paleontologist Matt Friedman was surprised to discover a remarkably detailed 319-million-year-old fish brain fossil while testing out micro-CT scans for a broader project.
The
#Hemichordate nervous system is
#chordate-like in its patterning but its neural architecture is unknown.
@jekely explores a
#PLOSBiology study revealing unexpected neuroanatomical complexity in these animals. Paper:
https://plos.io/46BtFWb Primer:
https://plos.io/46jQL3m
Molecular characterization of nervous system organization in the hemichordate acorn worm Saccoglossus kowalevskii
Hemichordates are crucial for understanding vertebrate nervous system origins. This study of the acorn worm Saccoglossus kowalevskii reveals a complex and regionalized neural plexus at the proboscis base that most likely acts as an integrative center, with widespread transmitter release throughout the epithelium and no division between central and peripheral nervous systems.
New insights into chordate body plan development answer long-standing questions on evolution
Life began on Earth more than 3.5 billion years ago, but the history of humans and other vertebrates accounts for only a fraction of this timescale. Chordates (a group that includes vertebrates) and echinoderms (like starfish and sea urchins) are believed to have evolved from a common deuterostome ancestor around 500 million years ago. However, how the complex and sophisticated body plan of chordates evolved is still not fully clear, despite its importance from an evolutionary and developmental biology perspective. This topic has thus been the subject of much debate among experts for a long time.
Scientist Accidentally Discovers The Oldest Brain of Any Vertebrate
Paleontologist Matt Friedman was surprised to discover a remarkably detailed 319-million-year-old fish brain fossil while testing out micro-CT scans for a broader project.
Parallel evolution of amphioxus and vertebrate small-scale gene duplications - Genome Biology
Background Amphioxus are non-vertebrate chordates characterized by a slow morphological and molecular evolution. They share the basic chordate body-plan and genome organization with vertebrates but lack their 2R whole-genome duplications and their developmental complexity. For these reasons, amphioxus are frequently used as an outgroup to study vertebrate genome evolution and Evo-Devo. Aside from whole-genome duplications, genes continuously duplicate on a smaller scale. Small-scale duplicated genes can be found in both amphioxus and vertebrate genomes, while only the vertebrate genomes have duplicated genes product of their 2R whole-genome duplications. Here, we explore the history of small-scale gene duplications in the amphioxus lineage and compare it to small- and large-scale gene duplication history in vertebrates. Results We present a study of the European amphioxus (Branchiostoma lanceolatum) gene duplications thanks to a new, high-quality genome reference. We find that, despite its overall slow molecular evolution, the amphioxus lineage has had a history of small-scale duplications similar to the one observed in vertebrates. We find parallel gene duplication profiles between amphioxus and vertebrates and conserved functional constraints in gene duplication. Moreover, amphioxus gene duplicates show levels of expression and patterns of functional specialization similar to the ones observed in vertebrate duplicated genes. We also find strong conservation of gene synteny between two distant amphioxus species, B. lanceolatum and B. floridae, with two major chromosomal rearrangements. Conclusions In contrast to their slower molecular and morphological evolution, amphioxus’ small-scale gene duplication history resembles that of the vertebrate lineage both in quantitative and in functional terms.
Börsposten
Kara Finance
Jon Awbrey
PLOS Biology
CellBioNews
Marc Robinson-Rechavi