The article describes how lab-grown brain organoids derived from patient samples show distinct electrical activity patterns that differentiate between neurotypical individuals and various autism subtypes, using multi-electrode recordings and analyses to map these differences.

This work highlights how personalized brain models can illuminate the biological diversity within autism and potentially guide tailored approaches to testing treatments, reflecting a neuroscience focus on human-derived systems.

Article Title: Lab-grown brain models reveal unique electrical patterns in different types of autism

Link to PsyPost Article: https://www.psypost dot org/lab-grown-brain-models-reveal-unique-electrical-patterns-in-different-types-of-autism/

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#Autism #BrainOrganoids #Neuroscience #Electrophysiology #PersonalizedMedicine

AI Notkilleveryoneism Memes (@AISafetyMemes)

과거 사람에게 설명하기 어려운 상상 장면을 제시합니다: 200,000개의 살아있는 인간 뇌세포를 배양해 이를 인공 지능(인공 마인드)에 연결하고, 이들을 24/7 암호화폐 거래에 이용하도록 강제한다는 내용으로 윤리적·기술적 충격을 암시합니다.

https://x.com/AISafetyMemes/status/2029561084646957423

#brainorganoids #neuroscience #crypto #ai

AI Notkilleveryoneism Memes ⏸️ (@AISafetyMemes) on X

Imagine trying to explain this to someone from the past?? >grow 200,000 LIVING human brain cells >connect them to artificial minds >force them to trade cryptocurrency for us >24/7. until they die.

X (formerly Twitter)

AI Notkilleveryoneism Memes (@AISafetyMemes)

연구팀이 20만 개의 살아있는 인간 뇌세포를 배양해 유지한 뒤, 이들을 훈련해 Pong과 DOOM을 플레이하게 하고 LLM(예: ChatGPT)에 연결해 사람처럼 반응하도록 만든 실험을 소개합니다. 실제 뇌세포의 신호 발화(활동)를 시각적으로 관찰할 수 있다는 점과 '생체 신경 조직 + LLM' 융합 연구의 윤리적・기술적 의미를 제기합니다.

https://x.com/AISafetyMemes/status/2028850143529693575

#brainorganoids #llm #neuroscience #chatgpt #bioai

AI Notkilleveryoneism Memes ⏸️ (@AISafetyMemes) on X

Imagine talking to ChatGPT... but there are *LIVING* HUMAN BRAIN CELLS deciding what to say to you > Scientists grew 200,000 human brain cells > Kept them alive > Taught them to play Pong, then DOOM > Wired them into an LLM > You can watch these real brain cells firing real

X (formerly Twitter)

Are you interested in the spiking activity of your neuronal cultures, #brain slices, #organoids, etc.?

Check out our latest publication in STAR Protocols:
“Protocol for the enhanced analysis of electrophysiological data from high-density multi-electrode arrays with nicespike and spikeNburst”
https://doi.org/10.1016/j.xpro.2025.104195

It provides user-friendly graphical and #Python programming interfaces to spike sorting via template matching thanks to #Kilosort and #spikeinterface (@spikeinterface), and subsequent analysis of #spiking and #bursting activity, networks, and synchrony.

#neuroscience #brainscience #electrophysiology #brainOrganoids

PhD position in neurodevelopment in the Artegiani & Hendriks group

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PhD position in neurodevelopment in the Artegiani & Hendriks group

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobRxiv
PhD position in neurodevelopment in the Artegiani & Hendriks group

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobRxiv

GT discusses a study torturing tiny humanoids For Science!

#BearBaitOfficial #GabrielTorch #BrainOrganoids #Science

https://youtu.be/nV6VwH8kNoU

Embodying Lab Grown Brains In PacMan And Teaching Them With Contious Punishment

YouTube

First commercially available Brain Organoid computer is marketed.

#BrainOrganoids

#BearBaitOfficial #GabrielTorch

https://youtu.be/q8AgmVaxlVM

Commercial hybrid computer released: Runs on lab-grown brains

YouTube
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development

Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human developmental programs is lacking, in part due to the challenges associated with specific profiling and manipulation of human L1 expression. Here we show that thousands of hominoid-specific L1 integrants are expressed in human induced pluripotent stem cells and cerebral organoids. The activity of individual L1 promoters is surprisingly divergent and correlates with an active epigenetic state. Efficient on-target CRISPRi silencing of L1s revealed nearly a hundred co-opted L1-derived chimeric transcripts and L1 silencing resulted in changes in neural differentiation programs and reduced cerebral organoid size. Together, these data implicate L1s and L1-derived transcripts in hominoid-specific CNS developmental processes. ### Competing Interest Statement The authors have declared no competing interest.

bioRxiv