Mastodawn

Are you interested in the spiking activity of your neuronal cultures, #brain slices, #organoids, etc.?

Check out our latest publication in STAR Protocols:
“Protocol for the enhanced analysis of electrophysiological data from high-density multi-electrode arrays with nicespike and spikeNburst”
https://doi.org/10.1016/j.xpro.2025.104195

It provides user-friendly graphical and #Python programming interfaces to spike sorting via template matching thanks to #Kilosort and #spikeinterface (@spikeinterface), and subsequent analysis of #spiking and #bursting activity, networks, and synchrony.

#neuroscience #brainscience #electrophysiology #brainOrganoids

RaymondPierreL3 Nov 21

"Time for global oversight of organoid work

Brain-organoid researchers are calling for global oversight as lab-grown mini-brains become increasingly complex and countries reduce reliance on animal models. Once primitive cell clusters, neural organoids can now mimic aspects of human brain development and disease — and even integrate into animal brains — prompting concerns over donor consent, animal welfare and the possibility of emerging sentience. “What does it mean if human cells are causing gains in animals’ abilities?” says bioethicist Insoo Hyun. “Currently, we’re not set up to deal with that.” The call to action was signed by 17 scientists across five countries."

There was nothing I could add to the above, except to say: This Is A Really Big Deal.

#Sentience #Organoids #BrainOrganoids #RegulatingOrganoidUse #Biology #Ethics #Philosophy #Morals

Reference: https://nature.us17.list-manage.com/track/click?

jobRxiv Nov 14

PhD position in neurodevelopment in the Artegiani & Hendriks group
Princess Maxima Center

See the full job description on jobRxiv: https://jobrxiv.org/job/princess-maxima-center-27778-phd-position-in-neurodevelopment-in-the-artegiani-hendriks-group/

#3Dcellculture #brainorganoids #earlybraindevelopment #neurodevelopment #organoids #ScienceJobs #hiring #researc...
https://jobrxiv.org/job/princess-maxima-center-27778-phd-position-in-neurodevelopment-in-the-artegiani-hendriks-group/?fsp_sid=5401

PhD position in neurodevelopment in the Artegiani & Hendriks group

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobRxiv

jobRxiv Oct 25

PhD position in neurodevelopment in the Artegiani & Hendriks group
Princess Maxima Center

See the full job description on jobRxiv: https://jobrxiv.org/job/princess-maxima-center-27778-phd-position-in-neurodevelopment-in-the-artegiani-hendriks-group/

PhD position in neurodevelopment in the Artegiani & Hendriks group

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobRxiv

jobRxiv Oct 4

PhD position in neurodevelopment in the Artegiani & Hendriks group
Princess Maxima Center

See the full job description on jobRxiv: https://jobrxiv.org/job/princess-maxima-center-27778-phd-position-in-neurodevelopment-in-the-artegiani-hendriks-group/

PhD position in neurodevelopment in the Artegiani & Hendriks group

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobRxiv

quangobaud Sep 11

GT discusses a study torturing tiny humanoids For Science!

#BearBaitOfficial #GabrielTorch #BrainOrganoids #Science

https://youtu.be/nV6VwH8kNoU

Embodying Lab Grown Brains In PacMan And Teaching Them With Contious Punishment

YouTube

quangobaud Mar 4

First commercially available Brain Organoid computer is marketed.

#BrainOrganoids

#BearBaitOfficial #GabrielTorch

https://youtu.be/q8AgmVaxlVM

Commercial hybrid computer released: Runs on lab-grown brains

YouTube

Amelia Cervera 🧬Jan 26

LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development.
#TransposableElements #Retrotransposons #LINE-1 #InducedPluripotentStemCells #BrainOrganoids #Preprint
https://www.biorxiv.org/content/10.1101/2025.01.17.633315v1

LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development

Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human developmental programs is lacking, in part due to the challenges associated with specific profiling and manipulation of human L1 expression. Here we show that thousands of hominoid-specific L1 integrants are expressed in human induced pluripotent stem cells and cerebral organoids. The activity of individual L1 promoters is surprisingly divergent and correlates with an active epigenetic state. Efficient on-target CRISPRi silencing of L1s revealed nearly a hundred co-opted L1-derived chimeric transcripts and L1 silencing resulted in changes in neural differentiation programs and reduced cerebral organoid size. Together, these data implicate L1s and L1-derived transcripts in hominoid-specific CNS developmental processes. ### Competing Interest Statement The authors have declared no competing interest.

bioRxiv

Dana Foundation Jan 6

🧠💡 Dr. Paola Arlotta discusses groundbreaking neurobiology, the role of #bioethics in research, and how funders can drive both scientific and ethical progress in the first #CivicScience Funders Collaborative Advisory Series.

https://civicsciencefellows.org/stories/civic-science-funders-collaborative-advisory-series-developing-neural-organoids-alongside-neuroethics-a-civic-science-conversation-with-paola-arlotta/

#BrainOrganoids #NeuroSociety