#Harmonine is a defense compound produced by the #Asian #ladybeetle #Harmoniaaxyridis
It is an important factor in beetle #immunity and has #BroadSpectrum #antimicrobial #activity #inhibiting the growth of #mycobacteria and demonstrating #multistage #antimalarial activity
The Asian lady beetle uses harmonine as a general hygiene measure, but switches to an effective defense strategy based on dozens of peptides when threatened

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297383/

https://www.mpg.de/7246516/Asian-lady-beetles

Harmonine, a defence compound from the harlequin ladybird, inhibits mycobacterial growth and demonstrates multi-stage antimalarial activity

The harlequin ladybird beetle Harmonia axyridis has been introduced in many countries as a biological control agent, but has become an invasive species threatening the biodiversity of native ladybirds. Its invasive success has been attributed to its vigorous ...

PubMed Central (PMC)

Scientists reveal machine learning could accelerate discovery of #antimalarial properties in #plants.

#AI #bioprospecting

https://phys.org/news/2023-05-scientists-reveal-machine-discovery-antimalarial.html

Scientists reveal machine learning could accelerate discovery of antimalarial properties in plants

A new study, published on May 25, 2023 in Frontiers in Plant Science by researchers at the Royal Botanic Gardens, Kew and partners, has identified that the use of machine learning could speed up the search for plants with antimalarial properties.

Phys.org
Antimalarial drug resistance on the rise in Africa

Artemisinin is the most important component in antimalarial drugs, but an increasing number of parasites in Africa are now resistant to it. If action isn't taken swiftly, the consequences could be disastrous.

Deutsche Welle
Rectal #artesunate, a promising #antimalarial drug, has no beneficial effect on the survival of young children with severe #malaria when used as an emergency treatment in resource-constrained settings.
#Medical #sflorg
https://www.sflorg.com/2022/12/med12202202.html
Antimalarial Drug Proves Ineffective at Saving Children’s Lives

Rectal artesunate (RAS) proves ineffective at saving the lives of young children suffering from severe malaria