Surviving war and #HIV: #Queer, HIV-Positive, and Running Out of Medication in #Gaza

by Afeef Nessouli, Steven W. Thrasher, January 13 2025

"Life in #NorthernGaza is precarious enough without having to worry about #AIDS. Airstrikes and ground raids are a constant threat that keep people from leaving their homes to find food. 'We have to conserve,' said E.S., a 27-year-old who lives with his mother and younger brother in the Tel al-Hawa neighborhood in southwest Gaza City. 'People are fighting each other to get the aid boxes.'

"And then there’s the issue of medication.

"'My doctor told me that the antiretrovirals have been consumed completely and there is nothing left in store,' said E.S., who is HIV-positive and agreed to speak with The Intercept using a pseudonym to avoid community stigma and targeting by the Israeli authorities.

"He needs #tenofovir, a common HIV medication, and #lopinavir / #ritonavir, a much more rarely prescribed one. At times, E.S. has had so little left that he dangerously began rationing his pills by skipping morning doses. 'There are no more supplies coming in or there hasn’t been any supplies at all coming in to the south or to the north,' he typed in a direct message. While Israel has denied blocking medication, international aid groups like #Glia have told The Intercept that HIV medication specifically has been blocked from entering the Gaza strip.

"Without these medications, E.S. — who already uses a walker for mobility — would see his health deteriorate rapidly. Within a short span of time, he would begin to move even more slowly, and he might lose the ability to walk altogether. With soldiers mandating mass displacement and sniping Palestinians as they try to evacuate, this could mean a death sentence.

"As Israel’s war on Gaza rages around him, E.S. has spent most of his time at home with his two cats. While many of his neighbors moved south to Rafah, he stayed put with his brother and mother, who is a cancer survivor. His limited mobility, the result of a viral infection exacerbated by HIV, made leaving more dangerous than staying.

"So they chose to stay north — despite warnings from the occupation military to evacuate. His home, while offering more protection than a tent, hasn’t exactly been safe: 'I saw people get sniped right across the street from me. It was a family of five trying to cross the road after they were ordered to evacuate their building before it was bombed.' He said the parents died and the children survived.

"E.S. used to get his medication from Al Rimal Martyrs Clinic, but it was evacuated and then reinhabited by displaced Palestinians.

"'Now, with the genocide happening, I fear not only my health deteriorating, but also how my family will respond,' he wrote. For years, his family didn’t acknowledge his HIV status; now he worries that his condition will be a liability for them."

Read more:
https://theintercept.com/2025/01/13/israel-gaza-war-hiv-aids-medication/
#NorthGaza #IsraeliWarCrimes #GazaAid #FreePalestine #CeasefireNow #IsraelHumanRightsViolations
#StopArmingIsrael #WorldWarBibi #BibiIsAWarCriminal #Genocide #Palestine #HumanRightsAreNeverWrong

Queer, HIV-Positive, and Running Out of Medication in Gaza

A year in Palestine, living in fear of not just genocide — but AIDS.

The Intercept
Wenn HIV-infizierte Patienten nach Beginn einer antiretroviralen Behandlung (ART) an Gewicht zulegen, kann dies ein Zeichen von Gesundung sein. Aber verschiedene ART-Substanzklassen und Einzelsubstanzen werden auch mit der Induktion von Übergewicht und Adipositas in Verbindung gebracht. In entsprechenden Studien allerdings war der Anteil der Teilnehmer, bei denen die Serokonversion zeitlich gut eingegrenzt werden konnte und das Körpergewicht dokumentiert war, oftmals klein.

Direktlink

https://www.bachhausen.de/aerzteblatt-de-hiv-1-therapie-unter-integrasehemmern-und-tenofovir-alafenamid-sind-staerkere-gewichtszunahmen-haeufig/

#aerzteblatt #alafenamid #integrasehemmern #starkere #tenofovir #therapie #unter

HIV-1-Therapie: Unter Integrasehemmern und Tenofovir-Alafenamid sind stärkere Gewichtszunahmen häufig

Wenn HIV-infizierte Patienten nach Beginn einer antiretroviralen Behandlung (ART) an Gewicht zulegen, kann dies ein Zeichen von Gesundung sein. Aber verschiedene ART-Substanzklassen und Einzelsubstanzen werden auch mit der Induktion von Übergewicht...

Deutsches Ärzteblatt
Specific suppression of long terminal repeat retrotransposon mobilization in plants

Plant tissue culture supplemented with the inhibitor of reverse transcriptase Tenofovir prevents mobilization of retrotransposons and increases genetic stabilit

OUP Academic

Of >50,000 persons with #HIV in Spain, those on TDF (#tenofovir disopropoxil fumarate) had

44% lower #COVID19 hospitalization risk

70% lower ICU admission risk

than those on TAF.

Work led by Julia del Amo.

https://journals.lww.com/aidsonline/Fulltext/2022/12010/Tenofovir_disoproxil_fumarate_emtricitabine_and.11.aspx

Evidence keeps mounting but no randomized trials yet.

Tenofovir disoproxil fumarate/emtricitabine and severity of ... : AIDS

Methods: We studied HIV-positive individuals on antiretroviral therapy (ART) in 2020 at 69 HIV clinics in Spain. We collected data on sociodemographics, ART, CD4+ cell count, HIV-RNA viral-load, comorbidities and the following outcomes: laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, COVID-19 hospitalization, intensive care unit (ICU) admission and death. We compared the 48-week risks for individuals receiving tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC), tenofovir alafenamide (TAF)/FTC, abacavir (ABC)/lamivudine (3TC), and other regimes. All estimates were adjusted for clinical and sociodemographic characteristics via inverse probability weighting. Results: Of 51 558 eligible individuals, 39.6% were on TAF/FTC, 11.9% on TDF/FTC, 26.6% on ABC/3TC, 21.8% on other regimes. There were 2402 documented SARS-CoV-2 infections (425 hospitalizations, 45 ICU admissions, 37 deaths). Compared with TAF/FTC, the estimated risk ratios (RR) (95% confidence interval) of hospitalization were 0.66 (0.43, 0.91) for TDF/FTC and 1.29 (1.02, 1.58) for ABC/3TC, the RRs of ICU admission were 0.28 (0.11, 0.90) for TDF/FTC and 1.39 (0.70, 2.80) for ABC/3TC, and the RRs of death were 0.37 (0.23, 1.90) for TDF/FTC and 2.02 (0.88–6.12) for ABC/3TC. The corresponding RRs of hospitalization for TDF/FTC were 0.49 (0.24, 0.81) in individuals ≥50 years and 1.15 (0.59, 1.93) in younger individuals. Discussion: Compared with other antiretrovirals, TDF/FTC lowers COVID-19 severity among HIV-positive individuals with virological control. This protective effect may be restricted to individuals aged 50 years and older....

LWW

Men with #HIV in the United States who were on TDF (#tenofovir disopropoxil fumarate) had

half the risk of #COVID19 hospitalization and ICU admission

than those on other antiretrovirals.

Work led by Katherine Li

https://pubmed.ncbi.nlm.nih.gov/35848570/

We adjusted for all known confounders. Alternative explanations anyone?

Tenofovir disoproxil fumarate and coronavirus disease 2019 outcomes in men with HIV - PubMed

Our study suggests that, in men living with HIV, TDF/FTC may protect against COVID-19-related events. Randomized trials are needed to investigate the effectiveness of TDF as prophylaxis for, and early treatment of, COVID-19 in the general population.

PubMed

TDF (#tenofovir disopropoxil fumarate) is a cheap, safe antiretroviral to treat and prevent #HIV.

#Observational studies have found that TDF users have a much lower risk of severe #COVID19 than users of other antiretrovirals (including TAF, another tenofovir prodrug).

How come no randomized trials of TDF exist? If interested in the repurposing of known antivirals to prevent serious #COVID19, watch my talk here

https://play.ki.se/media/Miguel+Hern%C3%A1n+-+22+03+2022/0_ge5wg9fm/373731

Links to the 2 most recent studies (just published) below.

Miguel Hernán - 22/03/2022 - KI PLAY