neat_newsScientists found a way to grow helper T cells from stem cells. The discovery could pave the way to develop new immune-based cancer therapies. See http://www.neat-news.com/3510.php. #T_cell
New research finds that some cancers seem to actively weaken T cells by particular signals so that the patient's immune system has problems fighting the cancer. The discovery opens a path to blocking these signals so that the T cells can recover their strength and fight the cancer. See http://www.neat-news.com/3464.php. #T_cell #cancer
Zeaxanthin, a supplement used for eye health and that occurs naturally in spinach and peppers, for instance, has been found to strengthen T-cell receptors and as a consequence improves the effect of immunotherapy in cancer treatment. More experiments are needed. See http://www.neat-news.com/3432.php. #zeaxanthin #supplement #T_cell #cancer_treatment
jobRxivPostdoctoral Researcher in Immunology
Brown University
Exciting postdoctoral position in mucosal immunology focused on immune-stromal interactions in female reproductive mucosa.
See the full job description on jobRxiv: https://jobrxiv.org/job/brown-university-27778-postdoctoral-researcher-in-immunology/?feed_id=72316
#3D_cell_culture #animal_models #immunology #T_cell #ScienceJobs #hiring ...
https://jobrxiv.org/job/brown-university-27778-postdoctoral-researcher-in-immunology/?feed_id=72316
Postdoctoral Researcher in Immunology
Brown University
Exciting postdoctoral position in mucosal immunology focused on immune-stromal interactions in female reproductive mucosa.
See the full job description on jobRxiv: https://jobrxiv.org/job/brown-university-27778-postdoctoral-researcher-in-immunology/?feed_id=71364
#3D_cell_culture #animal_models #immunology #T_cell #ScienceJobs #hiring ...
https://jobrxiv.org/job/brown-university-27778-postdoctoral-researcher-in-immunology/?feed_id=71364
πΈ"fitterhappierFan"-accountRT eric caroll
#Single-cell #multiomics revealed the #dynamics of #antigen presentation, #immune response and #T_cell #activation in the #COVID19 positive and recovered individuals
"we discovered that a subset of the naive #Tcells from the healthy #individuals were absent from the recovered individuals, suggesting a post-infection #inflammatory stage."
https://www.frontiersin.org/articles/10.3389/fimmu.2022.1034159/full
#SARS2 #sarscov2 #immunology #Immunity https://zeroes.ca/@EricCarroll/109536753305292464
Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals
IntroductionDespite numerous efforts to describe COVID-19's immunological landscape, there is still a gap in our understanding of the virus's infections after-effects, especially in the recovered patients. This would be important to understand as we now have huge number of global populations infected by the SARS-CoV-2 as well as variables inclusive of VOCs, reinfections, and vaccination breakthroughs. Furthermore, single-cell transcriptome alone is often insufficient to understand the complex human host immune landscape underlying differential disease severity and clinical outcome.MethodsBy combining single-cell multi-omics (Whole Transcriptome Analysis plus Antibody-seq) and machine learning-based analysis, we aim to better understand the functional aspects of cellular and immunological heterogeneity in the COVID-19 positive, recovered and the healthy individuals.ResultsBased on single-cell transcriptome and surface marker study of 163,197 cells (124,726 cells after data QC) from the 33 individuals (healthy=4, COVID-19 positive=16, and COVID-19 recovered=13), we observed a reduced MHC Class-I-mediated antigen presentation and dysregulated MHC Class-II-mediated antigen presentation in the COVID-19 patients, with restoration of the process in the recovered individuals. B-cell maturation process was also impaired in the positive and the recovered individuals. Importantly, we discovered that a subset of the naive T-cells from the healthy individuals were absent from the recov...