Having attempted to cover my first medical conference (#TLM22) using both Mastodon & Twitter, I can see the former isn't suited to this type of live coverage. Too slow & too cumbersome. On the other hand, Twitter remains fine for this. You can follow conference hashtags & not see any hint of politics, hate speech, or Musk's latest antics. It requires extra "infrastructure" cost (mainly my time) to use multiple platforms, but I think I'll stick with "different tools for different jobs."
