𝕵𝖆𝖒𝖎𝖊 🦠🔬💉#Covid #Pediatrichepatitis #肝炎
不明兒童肝炎已破千例，確診跟孩童闌尾炎有關聯，那肝炎呢？
該研究團隊分析確診者的T細胞受器(Cov-TCR)，發現：
-可識別肝細胞的過氧化體膜蛋白ABCD3
- 活化EBV
T細胞交叉反應可能是自體免疫樣肝炎（包含不明兒童肝炎）的原因之一
🔗：https://www.sciencedirect.com/science/article/pii/S2949928323000093
Liz HighleymanMainstream media & Twitter pundits may have moved on from this summer's mystery #PediatricHepatitis outbreak, but some of us are still paying attention. International repository collected data on 151 cases from 25 counties through 10/28/22. Cases peaked in May-June. About 3% of the children were immunocompromised, 10% (15 kids) were known to have had SARS-CoV-2 in past year, only 13% (20 kids) had received COVID vaccines (many were too young to be eligible). #LiverMtg22 #TLM22
ECDCRT @HelenBranswell: 1. Interesting update on #PediatricHepatitis from @ECDC_EU + @WHO_Europe. It contains the first epicurve I've seen, which is very helpful because reported cases include current & previous cases found through record searches. The 1st case here dates to Sept 2021.
RT @Eurosurveillanc: @ECDC_EU @Penta_ID @JankovanBeek @PeterHorby @Ecraid @PMeyerSauteur @NathalieBossuyt @GaschOriol_Inf Rapid communication:
Case numbers of acute #Hepatitis of unknown aetiology among #children in 24 countries up to 18 April 2022 compared to the previous 5 years
👇🏾
https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2022.27.19.2200370
#PediatricHepatitis
@JankovanBeek @MarionKoopmans @PeterHorby @Ecraid @…
Eurosurveillance | Case numbers of acute hepatitis of unknown aetiology among children in 24 countries up to 18 April 2022 compared to the previous 5 years
An increase of acute hepatitis of unknown aetiology has been reported among children in multiple countries worldwide. With a rapid online survey among hospitals in and outside of Europe, we describe case numbers recorded from 1 January to 18 April 2022 vs the previous 5 years. Of 24 countries that responded, we identified 5/17 European and 1/7 non-European countries with an elevation in probable cases of unexplained acute hepatitis, and severe cases were elevated in five European countries.