FOXO4-DRI = senescent cell eliminator
How it works:
→ FOXO4 normally binds p53 in senescent cells
→ FOXO4-DRI peptide displaces FOXO4
→ Free p53 triggers apoptosis
→ Senescent cells eliminated
Mouse studies: restored fur, kidney function, fitness
Selective killing = safe
Senolytics clear senescent cells—the "zombie cells" that accumulate with age and drive inflammation + disease.
The challenge: delivering them precisely to target cells, not healthy tissue.
Solution: nanoparticles + targeting ligands = drugs delivered only where needed.
Result: efficacy at lower doses, reduced toxicity.
Tested in: fibrosis, atherosclerosis, neurodegeneration.
Precision aging medicine is here.
🧬 Cellular Senescence: The Zombie Cells Within Us
Ever wonder why we age? Meet senescent cells - the "zombie cells" that stop dividing but refuse to die.
What happens:
→ Healthy cells become damaged (stress, DNA damage, telomere shortening)
The future of longevity? Senolytics - drugs that selectively eliminate these zombie cells, potentially reversing aspects of aging.
#CellularSenescence #AgingResearch #Longevity #Senolytics #RegenerativeMedicine #Geroscience
A pill to live to 150? 🧬🍇
Shenzhen’s Lonvi Biosciences is selling a grapeseed-derived PCC1 capsule it says clears “zombie cells” and could make 150-year lifespans realistic.
Our Biotech IE piece separates mouse data from marketing: senolytics, China’s longevity push, and what regulators might do next.
🔗 https://biotech.industryexaminer.com/china-150-year-grapeseed-longevity-pill-pcc1/
#Biotech #Longevity #Senolytics #AgingResearch #China #Geroscience #TechNews
Senescent Cells in Aged Tissues May Use Immune Checkpoints to Prevent Immune Clearance https://www.fightaging.org/archives/2024/08/senescent-cells-in-aged-tissues-may-use-immune-checkpoints-to-prevent-immune-clearance/
Immune clearance of senescence cells falters with age, becoming less efficient. This allows lingering senescent cells to accumulate, and their disruptive, inflammatory secretions contribute meaningfully to degenerative aging and age-related mortality. Greater knowledge of how exactly the immune system fails in its job may open novel avenues in the development of senolytic therapies to clear...
OK, so in essence dasatinib+quercetin does work, we just need to up the dosage.
Also, note that there is a dasatinib 1:1 equivalence in piperlongumine (https://www.nature.com/articles/s41598-024-55870-4/tables/3) that can be bought from here (https://www.mcsformulas.com/vitamins-supplements/piperlongumine-liposomal/).
I'm doing this as we speak.
Results from a Phase 2 Trial of Senolytic Therapy Dasatinib and Quercetin for Osteoporosis https://www.fightaging.org/archives/2024/07/results-from-a-phase-2-trial-of-senolytic-therapy-dasatinib-and-quercetin-for-osteoporosis/
Interesting venue of research . Not thought of that before. #medicine #aging #senolytics
Why Are Extraocular Muscles So Resilient to Aging? https://www.fightaging.org/archives/2024/05/why-are-extraocular-muscles-so-resilient-to-aging/
Most of us put little thought into the muscles that control the movement of the eye. They just work. Researchers here ask the interesting question: why are these extraocular muscles so resilient? Why does their function decline so little with age, when other muscles throughout the body lose strength and mass, leading ultimately to sarcopenia?...
Really good stuff here, a lot of new companies and therapies coming up that I didn't know of before. Good read.
#medicine #senolytics #biology
Notes from the Rejuvenation Startup Summit in Berlin, May 2024 https://www.fightaging.org/archives/2024/05/notes-from-the-rejuvenation-startup-summit-in-berlin-may-2024/
Repair Biotechnologies was invited to present at this year's Rejuvenation Startup Summit in Berlin, and so my CSO Mourad Topors and I attended. There were more people present this year than were at the already busy 2022 event. This is perhaps an indication of a still growing interest in the longevity industry as it expands,...
OK, interesting.. It is a bit hard to get hold of Dasatinib for sure.
In Search of Natural Senolytics to Substitute for Dasatinib https://www.fightaging.org/archives/2024/05/in-search-of-natural-senolytics-to-substitute-for-dasatinib/
Dasatinib and quercetin used in combination clears a fraction of lingering senescent cells in aging mice, producing a sizable degree of rejuvenation, and reversal of aspects of many different age-related conditions. In humans, clinical trials are underway at a sedate pace. Dasatinib is a chemotherapeutic small molecule, while quercetin is a plant extract flavonol. Here,...
Predicting the Order of Arrival of the First Rejuvenation Therapies https://www.fightaging.org/archives/2024/03/predicting-the-order-of-arrival-of-the-first-rejuvenation-therapies-2/
(SOme good pointers to existing and soon to come stuff)
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven...
Alice Frolov
Industry Examiner
Repeter wants an Ukr victory