A pill to live to 150? China’s grapeseed longevity hype gets right — and wrong - Biotech Industry Examiner

Lonvi Biosciences, a self-described “longevity laboratory”, has unveiled a capsule built around procyanidin C1 (PCC1), a molecule found in grape seeds. In its

Senescent Cells in Aged Tissues May Use Immune Checkpoints to Prevent Immune Clearance

Immune clearance of senescence cells falters with age, becoming less efficient. This allows lingering senescent cells to accumulate, and their disruptive, inflammatory secretions contribute meaningfully to degenerative aging and age-related mortality. Greater knowledge of how exactly the immune system fails in its job may open novel avenues in the development of senolytic therapies to clear...

Table 3 Selected natural compounds mimicking the treatment with dasatinib.

Why Are Extraocular Muscles So Resilient to Aging?

Most of us put little thought into the muscles that control the movement of the eye. They just work. Researchers here ask the interesting question: why are these extraocular muscles so resilient? Why does their function decline so little with age, when other muscles throughout the body lose strength and mass, leading ultimately to sarcopenia?...

Notes from the Rejuvenation Startup Summit in Berlin, May 2024

Repair Biotechnologies was invited to present at this year's Rejuvenation Startup Summit in Berlin, and so my CSO Mourad Topors and I attended. There were more people present this year than were at the already busy 2022 event. This is perhaps an indication of a still growing interest in the longevity industry as it expands,...

In Search of Natural Senolytics to Substitute for Dasatinib

Dasatinib and quercetin used in combination clears a fraction of lingering senescent cells in aging mice, producing a sizable degree of rejuvenation, and reversal of aspects of many different age-related conditions. In humans, clinical trials are underway at a sedate pace. Dasatinib is a chemotherapeutic small molecule, while quercetin is a plant extract flavonol. Here,...

Predicting the Order of Arrival of the First Rejuvenation Therapies

It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven...

Cell senescence, the senescence-associated secretory phenotype, and cancers

In this Perspective, the authors look back at a 2008 PLOS Biology article that reported a senescence-associated secretory phenotype that could promote inflammation and cancer, and discuss how that discovery eventually enabled the development of senolytic drugs.

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