What determines whether we become overweight? A #CharitéBerlin study shows that aside from lifestyle and genes, a kind of formatting of a satiety gene also increases the risk of #obesity – at least in women. This “epigenetic marking” is established early on during the embryonic stage.

👉 https://www.charite.de/en/service/press_reports/artikel/detail/more_than_just_lifestyle_and_genes_new_factor_influencing_excess_body_weight_discovered/

#Medicine #Science #Research #ScienceMastodon #MedMastodon #CharitéPaper #CharitéPediatrics #Epigenetics #POMC #ScienceTranslationalMedicine

Was bestimmt, ob wir fettleibig werden? Eine #CharitéBerlin-Studie zeigt: Neben Lebensstil & Genen steigert auch eine Art Formatierung eines Sättigungsgens das #Adipositas-Risiko – zumindest bei Frauen. Diese „epigenetische Markierung“ wird schon in der Embryonalphase etabliert.

👉 https://www.charite.de/service/pressemitteilung/artikel/detail/nicht_nur_lebensstil_und_gene_weiterer_einflussfaktor_fuer_uebergewicht_entdeckt/

#Medizin #Wissenschaft #Forschung #Übergewicht #CharitéPaper #CharitéPädiatrie #MedMastodon #ScienceMastodon #Epigenetik #POMC #ScienceTranslationalMedicine

Human immunology from the Eisenbarth lab

"The aim of our study was to characterize infant gut food-specific IgA responses and determine whether gut and plasma food-specific IgA are related to tolerance to food allergens. We found that non–food-allergic infants make gut peanut-specific IgA. We next demonstrated that gut peanut-specific IgA did not correlate with measures of future peanut allergy outcome nor did it correlate with peanut tolerance. We also observed that gut egg white-specific IgA was higher in egg-allergic children and did not predict outgrowth of egg allergy. Our data also revealed that there are no differences in the epitopes targeted by gut peanut-specific IgA between peanut-allergic and nonallergic children but that epitope specificity is different between gut peanut-specific IgA and plasma peanut IgE. Overall, these findings challenge the commonly presumed protective role of food-specific IgA."

#Immunology #Allergy
#ScienceTranslationalMedicine

https://www.science.org/doi/10.1126/scitranslmed.abq0599