🧬 One amino acid to stabilize them all — myth or molecular reality?
🔗 Single-residue engineering of lambda (λ) antibody light chains reduces conformational flexibility and enhances thermal stability. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.045
📚 CSBJ: https://www.csbj.org/
#MonoclonalAntibodies #mAbs #Immunology #ComputationalBiology #MolecularDynamics #Bioinformatics #ProteinStability #StructuralBiology
19-JUL-2023
New method expertly evaluates protein folding stability on a large scale
https://www.eurekalert.org/news-releases/995603 title of the paper in Nature isn't much clearer: Mega-scale experimental analysis of protein folding stability in biology and design, #science #nanoworld #ProteinFolding #ProteinStability #proteins
Researchers at Northwestern University and recently joining the Institute for Industrial Science, The University of Tokyo developed a method to evaluate the folding stability of a million proteins simultaneously. DNA libraries were used to generate protein–DNA complexes that were treated with enzymes to destroy unfolded proteins. The intact proteins were identified by DNA sequencing. This system can describe the factors that keep protein structure and advance our understanding of diseases involving protein misfolding.
Really pleased that my awesome student Tej is literally getting her project 'off the ground' ...
"Nottingham students’ astropharmaceutical project set to be sent into space"
A team of students have beaten competition from across Europe, becoming the first UK group to be selected for the “Orbit Your Thesis” competition to send their self-developed experiment to the International Space Station (ISS).
CSBJ
michael
Prof Anna K Croft