Dr. ThompsonMar 3

AI just cut drug discovery time by 75%. 🧬

MIT’s protein-generating model designs life-saving molecules in weeks — not years. Rare diseases may finally get viable treatments.

Read before this shifts the pharma equation. 👇
https://medium.com/@rogt.x1997/mits-protein-ai-revolution-04a728edcac4

#ProteinAI #DrugDiscovery #Biotech
https://medium.com/@rogt.x1997/mits-protein-ai-revolution-04a728edcac4

MIT’s Protein AI Revolution

Cutting Drug Costs by Billions and Accelerating Cures

Medium
Cyrus BiotechnologyFeb 1, 2023
Exciting to see a new protein generative diffusion model in preprint! We look forward to trying the Genie model from Mohammed AlQuraishi https://www.aqlab.io/. The preprint is here and we hear that the code will be released soon. https://arxiv.org/abs/2301.12485 #ai #proteinengineering #proteinai #drugdiscovery
AlQuraishi Lab at Columbia University

Machine learning biomolecules and their interactions en route to a bottom-up and emergent systems biology.

Lucas NivonFeb 1, 2023
Exciting to see a new protein generative diffusion model in preprint! We look forward to trying the Genie model from Mohammed AlQuraishi https://www.aqlab.io/ https://arxiv.org/abs/2301.12485 #ai #proteinengineering #proteinai #drugdiscovery
AlQuraishi Lab at Columbia University

Machine learning biomolecules and their interactions en route to a bottom-up and emergent systems biology.

Cyrus BiotechnologyJan 11, 2023
Great summary of recent protein diffusion #ai models from the Baker lab and Namrata Anand (Stanford) in the NYT! We are excited for the diffusion models to start making an impact on de novo design for drug discovery.#proteinai #drugdiscovery (unpaywalled link) https://www.nytimes.com/2023/01/09/science/artificial-intelligence-proteins.html?unlocked_article_code=s_t7RtEDLdq2lgWJVCDjST--kz1rNphFpK5JwwsY9MvrUcwEsT8n6283SCFhPegB8WtXsL-cg2Tcwye7A1MJ-rcpkAT4uNId6quZdVYF51cmHT7aRBQZkstB3i8oNwykLu3Ye-jM2RFUEWz4URM4ZvLyO8mfV6cQVQ3_7eyVO9dcpSQeJInuj93Z7Jm0iMsIF1SnKQeVmb1S5YRsWYSy2wK-9I_TxWUf7H3vAZo0NRXcRkozp6IjLgVk8MsZusv_0Q0556-zMv219q4wy-3YDrj3sPTuuuF652OxSmkfcm3w7dFBknvTRhMWKZTDoCWAdK5W73FYd0RIDlzYwsOyVqqG9hBBZO6xkQ&smid=share-url
A.I. Turns Its Artistry to Creating New Human Proteins

Inspired by digital art generators like DALL-E, biologists are building artificial intelligences that can fight cancer, flu and Covid.

Show threadCyrus BiotechnologyJan 4, 2023
@sokrypton Congrats all! Very exciting to push this combination of language models and structure models. AF2 and OF have been frustrating for design, not too surprisingly, but this all makes a ton of sense as a next step! #drugdiscovery #ai #proteinai #proteindesign
Show threadLucas NivonDec 4, 2022
This paper is impressive because it introduces the model and more importantly demonstrates working designs including a very strong (strongest yet?) de novo binding protein. Also unusually high success rate. Protein design already often works, this is a significant improvement for re novo. Critical to show these data! Lots of impressive past designs failed in the lab #biotech #proteinai #ai
Lucas NivonNov 23, 2022
Quoting Mohammed AlQuraishi (Columbia U) from Twitter: OpenFold preprint is out! https://www.biorxiv.org/content/10.1101/2022.11.20.517210v1 Much richer story than expctd 1) AF2 shockingly robust to data elision; train on 1k chains→get AF1 acc; train on helices or sheets→do ok on other 2) it learns 1D→2D→3D proteins. Tweetorial in Gustaf Ahdritz's twitter today #biotech #ai #proteinai #drugdiscovery
Lucas NivonNov 22, 2022
Our company @cyrusbiotech is not here yet, but we are excited to announce our Free and Open Source consortium in biomolecular #ai is growing #proteinai https://www.businesswire.com/news/home/20221122005163/en/%C2%A0OpenFold-AI-Research-Consortium-Welcomes-4-New-Members-Bayer-Dassault-CHARM-Therapeutics-and-BaseCamp-Research
 OpenFold AI Research Consortium Welcomes 4 New Members: Bayer, Dassault, CHARM Therapeutics and BaseCamp Research

Four new companies join OpenFold, an AI Research group dedicated to developing open source tools for new drug discovery.

Show threadLucas NivonNov 19, 2022
@KevinKaichuang maybe there can be something here like #proteinai or similar? Search ability here relies more on hashtags