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A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis.

Link: https://www.pnas.org/doi/10.1073/pnas.2211977120

#Immunology #DrugDelivery #SyntheticBiology #Probiotics #VenomToxins #PotassiumChannels #RheumatoidArthritis #Autoimmunity #Immunomodulator #Physiology

Study shows shaker channel mutation differs structurally from human potassium channels

Potassium (K+) channels are small, highly specialized conduits within every living cell that are responsible for the extremely selective and rapid transport of K+ ions across cell membranes. Voltage-gated potassium (Kv) channels are potassium-specific transmembrane channels that also are sensitive to voltage changes within the cell's membrane where a selectivity filter chooses K+ ions over sodium (Na+).

Phys.org