The National Institutes of Neurological Disorders and Stroke (NINDS) and American Brain Coalition (ABC) are co-hosting a high-impact event that highlights the power of public-private partnerships and celebrates decades of progress in brain science. Join them on Wednesday, June 25, in-person or online.
More details can be found here:https://www.americanbraincoalition.org/page/PPPNINDSNonprofitForum
Tomorrow, June 24, the National Institute of Neurological Disorders and Stroke (NINDS) is celebrating 75 years with a special congressional briefing and reception. This event will spotlight the scientific advancements made possible by NINDS over the past 75 years—from foundational discoveries in brain function to life-changing therapies for neurological diseases.
RSVP here: https://docs.google.com/forms/d/e/1FAIpQLSfDttWdlAgcABaQJYV6uKhlnLyqMWdnrlzY_dqSETBK29JVIw/viewform
Event Timing: Tuesday, June 24, 2025 - 3:30-5:00pm ET Event Address: Longworth House Office Building Room 1539, Capitol Hill, Washington, DC Snacks and refreshments will be provided
Excited to share our story describing network of myeloid and CD8 T cell activation programs underlying chronic neuroinflammation in MS.
Really thankful to Daniel Reich and all collaborators for this project, and the funding mechanisms. #TNS #NINDS #PRL #MS
Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T cell-mediated cytotoxicity. https://www.biorxiv.org/content/10.1101/2025.06.09.658729v1
Chronic neuroinflammation and neurodegeneration are critical but unresolved drivers of disability accumulation in progressive multiple sclerosis (MS). Chronic active white matter lesions (CAL), identifiable radio-logically as paramagnetic rim lesions (PRL), indicate progression-relevant chronic neuroinflammation. Using single-cell transcriptomics (scRNAseq) and T-cell receptor sequencing (scTCR-seq), we profiled cerebrospinal fluid (CSF) and blood immune cells of 34 radiologically characterized adults with MS (17 untreated, 6 treated with B-cell-depletion) and 5 healthy controls. Coupled with proteomics, we found PRL-associated enrichment of interferon (IFN) signaling and upregulation of TCR signaling in CSF and blood. This was accompanied by clonal expansion of CD8+ T effector memory (TEM) cells, with the highly expanded clonal cells exhibiting T helper type 1 (TH1) and cytotoxic profiles. Validating the cytotoxic immune profile in blood using flow cytometry, we identified a cellular correlate of PRL exhibiting features of CD8+ TEMRA cells. Despite B-cell depletion, PRL-associated neuroinflammation, driven by myeloid activation and CD8+ T-cell cy-totoxicity, persisted. Serum and CSF proteomic networks showed PRL-pertinent signatures, including net-works unaffected by B-cell depletion. Using in silico perturbation, we nominated therapeutic targets, including MYD88, TNF, MYC, TYK2, JAK2, and BTK, for alleviating chronic neuroinflammation in MS. Our findings highlight mechanisms of chronic neuroinflammation in MS and point to potential biomarkers for moni-toring disease progression. ### Competing Interest Statement The authors have declared no competing interest. Sanofi (United States), https://ror.org/027vj4x92 Abata Therapeutics National Institutes of Health, https://ror.org/01cwqze88
The National Institute of Neurological Disorders and Stroke (NINDS) and the American Brain Coalition invite members of nonprofit organizations to an annual Nonprofit Forum on June 25.
The Progress through Partnership Forum provides an opportunity for nonprofit leaders to network with colleagues and to engage in discussions with NINDS staff.
Register to attend in person or virtually: https://www.ninds.nih.gov/news-events/events/2025-ninds-nonprofit-forum
After 'coding error' triggers firings, top NIH scientists called back to work | Hacker News
Link📌 Summary:"Multiple #NIH sources tell WIRED the layoffs include—in addition to labor, IT, and human resources personnel—several accomplished senior investigators at the National Institute of Neurological Disorders and Stroke (#NINDS), top scientists at the National Institute on Aging, and several researchers noted for their work in HIV, emerging infectious diseases, and child brain and neural disorders."
#trump #musk #doge #project2025
https://www.wired.com/story/doctor-breakthrough-parkinsons-research-nih-purge/
RT @YensiFB: Insightful discussions at the #NINDS /#NIH workshop on novel approaches to to prevent publication bias. Hearing the need for #…
— CoARA (@CoARAssessment)
May 21, 2024
May 21, 2024 at 01:57PM
via Twitter https://twitter.com/CoARAssessment
Congratulations to the recipients of #NINDS Rigor Champions Prize! The prize recognizes and rewards “individuals and small teams who have championed rigor and transparency practices”.
See the list recipients and honorable mentions 👇
The NINDS Office of Research Quality seeks to promote research rigor and transparent reporting and to foster a culture of research quality within the scientific ecosystem. As part of this mission, NINDS launched the NINDS Rigor Champions Prize in 2023.
From Medscape:
Long COVID: Who's Working to Find Treatments?
https://www.medscape.com/viewarticle/984510
"Dr Walter Koroshetz, director of the National Institute of Neurological Disorders and Stroke, talks with Medscape contributing editor Maggie Fox (@maggiefox) about the goals of the clinical trials being sponsored by the National Institutes of Health."
Video with transcript.
#COVID #COVID19 #LongCovid #NIH #NINDS #Medscape #PatientLed #Research #Treatment
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