`Through genome-wide CRISPR screening, we identified the RNA-binding protein DHX29 as a critical regulator of codon-dependent gene expression. Cryogenic electron microscopy and selective ribosome profiling demonstrated that DHX29 directly interacts with the A-site entrance of the translating 80S ribosome... These findings establish a mechanistic link between synonymous codon usage and the regulation of gene expression.`

http://dx.doi.org/10.1126/science.adw0288

#codon #synonymousCodon #eukaryotes #mRNA #DHX29

愛狗患癌工程師搵 AI 幫手 ChatGPT 設計癌症疫苗 腫瘤縮 75% 重拾活力 - unwire.hk 香港

在缺乏合適藥物選擇情況下,Conyngham 決定自己想辦法。他先為腫瘤做 DNA 定序,將腫瘤組織「由組織變成數據」,再用 AI 工具找出關鍵突變和潛在攻擊目標。他表示用 ChatGPT 幫手擬定整體計劃、閱讀學術論文、梳理實驗步驟,再配合 Google DeepMind 的 AlphaFold

香港 unwire.hk 玩生活.樂科技
愛狗患癌工程師搵 AI 幫手 ChatGPT 設計癌症疫苗 腫瘤縮 75% 重拾活力 - unwire.hk 香港

在缺乏合適藥物選擇情況下,Conyngham 決定自己想辦法。他先為腫瘤做 DNA 定序,將腫瘤組織「由組織變成數據」,再用 AI 工具找出關鍵突變和潛在攻擊目標。他表示用 ChatGPT 幫手擬定整體計劃、閱讀學術論文、梳理實驗步驟,再配合 Google DeepMind 的 AlphaFold

香港 unwire.hk 玩生活.樂科技
Rosie's cancer vaccine shows promise, but headlines misstate what AI actually did

Rosie's tumour shrank 75% after a personalised mRNA vaccine. But experts warn headlines overstate AI's role and overlook critical limitations of the treatment.

The Daily Perspective
A single injection of #mRNA-like treatment could help heart muscle heal after a heart attack in mice and pigs. Could it work in humans too? https://www.livescience.com/health/a-single-injection-of-mrna-like-treatment-could-help-heart-muscle-heal-after-a-heart-attack-in-mice-and-pigs-could-it-work-in-humans-too
A single injection of mRNA-like treatment could help heart muscle heal after a heart attack in mice and pigs. Could it work in humans too?

Researchers boosted levels of a heart-healing hormone in mice and pigs with a single injection of a new, experimental form of self-amplifying RNA that prolonged hormone synthesis for many weeks.

Live Science
Cancer vaccines could transform treatment and prevention – but misinformation about mRNA vaccines threatens their potential

False claims that COVID-19 mRNA vaccines cause cancer could, ironically, lead to worse cancer outcomes by undermining a promising tool to prevent and treat it.

The Conversation
I sure hope she doesn’t need an #mRNA therapy her own administration roadblocked.

Scientists call it the first personalized cancer vaccine ever made for a dog.

#AI #CancerResearch #mRNA #Grok

Guy uses #AI to create custom #mRNA cancer vaccine for his #dog. He sequenced the dog's tumors and general genomes to find variants unique to the cancer. Probably used AlphaFold to design a peptide that binds to mutated but not normal proteins. mRNA vaccine causes dog's body to synthesize peptide.

mRNA vaccine technology is truly amazing. I don't think we've even come close to realizing its full potential for quickly producing new general or custom drugs.

https://finance.yahoo.com/news/mans-dog-riddled-tumors-dying-210500037.html

Man's dog was riddled with tumors and dying. He used ChatGPT to design a custom cancer vaccine, stunning researchers

With no biology degree and just $3,000, he designed a personalized mRNA vaccine in a world first. Moderna and Merck are spending billions to bring the same...

Yahoo Finance

Andrew Mayne (@AndrewMayne)

트윗은 'AI는 단순 토큰 예측'이라는 통념에서 출발해 곧바로 'ChatGPT로 맞춤형 mRNA 연구를 잘못한다'는 반응이 생겼다고 언급하며, ChatGPT를 이용한 mRNA 연구 사례에 대한 빠른 사회적·전문적 반응 변화를 지적합니다. ChatGPT의 바이오 응용 사례에 대한 논쟁을 반영합니다.

https://x.com/AndrewMayne/status/2033246189509107887

#chatgpt #mrna #bioinformatics #ai

Andrew Mayne (@AndrewMayne) on X

We went from “AI is just a next token predictor” to “Awkshully you’re doing custom mRNA research with ChatGPT all wrong” real quick.

X (formerly Twitter)