Mastodawn

"These results have broad implications for biological processes regulated by membrane potential, particularly in contexts such as neuronal signaling, where condensate interactions with membranes may play a previously unrecognized regulatory role."

#neuron #condensates #cellMembrane #membranePotential

Fabrizio Musacchio Apr 22, 2024

An important step in #ComputationalNeuroscience 🧠💻 was the development of the #HodgkinHuxley model, for which Hodgkin and Huxley received the #NobelPrize in 1963. The model describes the dynamics of the #MembranePotential of a #neuron 🔬 by incorporating biophysiological properties. See here how it is derived, along with a simple implementation in #Python:

🌍 https://www.fabriziomusacchio.com/blog/2024-04-21-hodgkin_huxley_model/

Feel free to share and to experiment with the code.

#CompNeuro #PythonTutorial #NeuralDynamics #DynamicalSystem

Hodgkin-Huxley model

An important step beyond simplified neuronal models is the Hodgkin-Huxley model. This model is based on the experimental data of Hodgkin and Huxley, who received the Nobel Prize in 1963 for their groundbreaking work. The model describes the dynamics of the membrane potential of a neuron by incorporating biophysiological properties instead of phenomenological descriptions. It is a cornerstone of computational neuroscience and has been used to study the dynamics of action potentials in neurons and the behavior of neural networks. In this post, we derive the Hodgkin-Huxley model step by step and provide a simple Python implementation.

Fabrizio Musacchio

PLOS Biology Jan 19, 2023

Heterogeneity of #bacterial #MembranePotential. During colony development of the human #pathogen N. gonorrhoeae, the population transitions from heterogeneous to collective membrane polarization dynamics, marking the onset of habitat diversity #PLOSBiology https://plos.io/3wgrMxT

Collective polarization dynamics in bacterial colonies signify the occurrence of distinct subpopulations

Membrane potential in bacterial systems has been shown to be dynamic and tightly related to survivability at the single cell level. This study of the the human pathogen Neisseria gonorrhoeae shows that during bacterial colony development, the population transitions to from heterogeneous to collective membrane polarization dynamics, marking the onset of habitat diversity.

PLOS Biology Jan 19, 2023

Heterogeneity of #bacterial #MembranePotential. During colony development of the human #pathogen N. gonorrhoeae, the population transitions from heterogeneous to collective membrane polarization dynamics, marking the onset of habitat diversity #PLOSBiology https://plos.io/3wgrMxT

Collective polarization dynamics in bacterial colonies signify the occurrence of distinct subpopulations

Membrane potential in bacterial systems has been shown to be dynamic and tightly related to survivability at the single cell level. This study of the the human pathogen Neisseria gonorrhoeae shows that during bacterial colony development, the population transitions to from heterogeneous to collective membrane polarization dynamics, marking the onset of habitat diversity.

PLOS Biology Jan 19, 2023

Heterogeneity of #bacterial #MembranePotential. During colony development of the human #pathogen N. gonorrhoeae, the population transitions from heterogeneous to collective membrane polarization dynamics, marking the onset of habitat diversity #PLOSBiology https://plos.io/3wgrMxT

Collective polarization dynamics in bacterial colonies signify the occurrence of distinct subpopulations

Membrane potential in bacterial systems has been shown to be dynamic and tightly related to survivability at the single cell level. This study of the the human pathogen Neisseria gonorrhoeae shows that during bacterial colony development, the population transitions to from heterogeneous to collective membrane polarization dynamics, marking the onset of habitat diversity.

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