dgspsoaRE: https://social.bund.de/@RKI/116278135150350944
Helft mit.
Man kann übrigens auch von #FSME und #DengueFieber #MEcfs bekommen.
Ente_Bullitt
Mariaislc-pais.org
#ME/cfs #PAIS #LongCovid
World experfd LongCovid Pais 26-29 August 2026 in Amsterdam
ISLC-PAIS Conference 2026 in A...
ISLC-PAIS Conference 2026 in A...
Science4ME News BotClinical practice guideline for long COVID prevention and treatment — Bin Cao et al
"most evidence came from observational studies of variable quality, leading to low to very low certainty of evidence for many recommendations due to bias, inconsistency (e.g., high I² values in meta-analyses), and imprecision."
https://publications.ersnet.org/content/erj/early/2026/03/05/1399300302611-2025
Clinical practice guideline for long COVID prevention and treatment
BackgroundThis guideline aims to address key clinical questions of long COVID, and to provide evidence-base recommendations. The target population is adults with long COVID. The primary users of the guideline are clinical physicians, clinical pharmacists, nurses, and general practitioners in community healthcare institutions worldwide.MethodsThe guideline was registered at the Practice guideline REgistration for transPAREncy platform (PREPARE-2024CN123) and followed a pre-specified protocol. A multidisciplinary working group was established and comprised 60 members from 10 countries and 10 area of expertise, with a strong background in long COVID research and clinical practice, and methodology of guideline development. Through a two-step process, we determined the 8 PICO questions focusing on prevention and treatment of long COVID. After comprehensively searching literature, conducting systematic reviews, and investigating patients’ values and preferences, three rounds of Delphi survey were conducted among 24 international experts to reach consensus. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was applied to rate the certainty of evidence and determine the strength of recommendations.ResultsThe guideline presents 10 specific recommendations, each supported by existing, updated, or newly conducted systematic reviews. The key recommendations are pertinent to the following issues: 1) suggestion of vaccination or use of antiviral agents during the acute phase of COVID-19 to prevent long COVID; 2) suggestions against the use of nirmatrelvir-ritonavir and glucocorticoids (patients with persistent respiratory symptoms and olfactory disorders) for long COVID treatment; 3) suggestions supporting the use of multi-species probiotics, cognitive behavioral therapy (patients with fatigue), and personalized rehabilitation after excluding post-exertional malaise for long COVID treatment.ConclusionsThis guideline provides evidence-based recommendations for the prevention and treatment of long COVID. Given the limited and often low-methodological quality evidence, all recommendations are supported by very low to moderate certainty. Further high-quality studies are needed to strengthen the evidence base.
Long-term trends in Post-COVID severity: a machine learning analysis from the POP/COVIDOM cohort of the German NAPKON Cohort Network — Julian Gutzeit et al
"Most patients showed little change in their symptoms over time, and differences between individuals remained quite stable." "This suggests that once post-COVID symptoms are established, they tend to remain relatively stable, with only modest and uniform improvement in most patients."
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(26)00069-6/abstract
LassitudorBei #MECFS begegnet man Ärzten, die für alle Beschwerden andere Ursachen finden wollen (gern genommen: Depressionen) und Ärzten, die alles auf MECFS schieben. So bei mir. Zwei Jahre hat man meine Arm- und Schulterschmerzen auf meine Krankheit geschoben, bis irgendwann mal ein Arzt auf die Idee kam, mich mit Röntgen, CT und MRT zu untersuchen. Die dabei entdeckten kaputten Bandscheiben sind jetzt erfolgreich entfernt. Nachteil: die lange Quetschung der Nerven durch die kaputten Bandscheiben 1/2
Severe acute COVID-19 and early long COVID signals in paediatric cohorts: an analysis of real-world data from two health departments, Germany — Schmidt et al
"Increasing evidence suggests an association between severe acute COVID-19 in children and ME/CFS-like sequelae"
https://link.springer.com/article/10.1186/s12887-026-06724-7
Severe acute COVID-19 and early long COVID signals in paediatric cohorts: an analysis of real-world data from two health departments, Germany - BMC Pediatrics
Severe acute coronavirus disease 2019 (COVID-19) is uncommon in children; however, its development can lead to longer-term health problems. Understanding f
Persistence of Post-Acute COVID-19 Sequelae (PASC) symptoms in healthcare workers four years after ancestral SARS-CoV-2 infection: a prospective multicentre cohort — Saurer et al
"In a prospective multicentre cohort of HCWs, we demonstrate a non-linear decline in PASC-specific symptoms over time, with up to 60% of individuals still reporting symptoms after a median of almost 4 years after aSCV2 infection."
https://link.springer.com/article/10.1007/s15010-026-02768-0
Persistence of Post-Acute COVID-19 Sequelae (PASC) symptoms in healthcare workers four years after ancestral SARS-CoV-2 infection: a prospective multicentre cohort - Infection
Purpose Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), or long COVID (LC), remains a significant burden for public health, with limited long-term data. This study aimed to assess the prevalence and evolution of PASC symptoms after ancestral SARS-CoV-2 (aSCV2) infection in a longitudinal healthcare worker (HCW) cohort. Methods A multicentre cohort study involving HCWs from 14 institutions was conducted in Switzerland. Infection status was based on self-reported positive swabs, with additional serology used to confirm uninfected controls. Baseline was defined as the first survey conducted in 2022 (median 18.5 months post-infection), with follow-up surveys every 6 months through November 2024. To identify PASC-specific symptoms, 24 chronic symptoms were compared between 456 aSCV2-infected and 571 uninfected participants using chi-square tests at baseline. In aSCV2-infected individuals reporting PASC-specific symptoms, symptom trajectories and subjective LC were analyzed across follow-up surveys. Functional limitations were assessed using the Post-COVID Functional Status (PCFS) scale. Results Thirteen of 24 symptoms were more common in aSCV2-infected individuals, with fatigue (22.8%), loss of smell/taste (11.4%), and brain fog (8.3%) being most prevalent. At baseline, 186/456 (40.8%) infected participants reported ≥ 1 PASC-specific symptom. Most symptoms declined in prevalence up to the last survey (median 47.5 months post-infection), although 41/70 (58.6%) remaining participants still reported ≥ 1 PASC symptom. Subjective LC was reported by 70/186 (37.6%) and was associated with higher symptom burden. PCFS scores showed slight impairments in most cases, although moderate-to-severe limitations often persisted. Conclusions PASC symptoms persisted up to four years after aSCV2 infection in a substantial proportion of HCWs.
Will 
It sure seems like my particular cocktail of health conditions limits my ability to bounce back from surgeries, injuries, and some illnesses. Normally physical therapy is prescribed to get you from corrected to healed for the long term.
With my particular major conditions (Sjogren's with the all-over body pain and ME/CFS for post exertional malaise), if I attempt PT either in clinic or at home, I flare up badly for nearly a week every time. And this occurs regardless of the body parts being rehabilitated. With it effectively shutting down my life for a week at a time, it's not sustainable nor practical.
It's a bit discouraging that I am more disabled than I might otherwise be because of this. And it appears to some clinicians as noncompliant or malingering. But knowing my limitation, I can guide life choices accordingly to get the best possible life despite the physical limitations.
#PhysicalTherapy #MECFS #ChronicFatigueSyndrome #SjogrensDisease #PostExertionalMalaise
Persistent T cell phenotypic alterations and early innate immune dysregulation as potential biomarkers of Long COVID — Marina Perez-Mazzali et al
Hospitalised patients. "during the acute stage of the disease, differences between patients who subsequently developed LC are mainly found in the innate immunity compartment, while 3 months after hospital discharge these differences are related to the adaptive immune system."
https://www.journalofinfection.com/article/S0163-4453(26)00056-3/abstract