"… widespread alterations in cerebral microstructure, attributed to a shift in volume from neuronal compartments to free fluid, associated with the severity of the initial infection. Correlating these alterations with cognition, olfaction, and fatigue unveils distinct affected networks, which are in close anatomical-functional relationship with the respective symptoms."
After contracting COVID-19, a substantial number of individuals develop a Post-COVID-Condition with neurological symptoms. Here, the authors show symptom-specific brain microstructure alterations in these patients, providing insights into the underlying pathophysiology.
"In a large prospective cohort of people who underwent testing a median of 9 months after acute COVID-19…we found that cognitive dysfunction is common [and] is not influenced by mood, fatigue, or sleepiness"
"we report PASC-CI to have cognitive deficits independent from depression and anxiety symptoms, to be molecularly distinct from AD [Alzheimer's], and to associate with dysregulated IFN- and chemokine-related genes"
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00253-2
PET neuroimaging found Long COVID patients have more neuroinflammation than healthy controls. This inflammation was located in brain areas that were exposed to circulating blood factors via gaps in the blood-brain barrier; the researchers found that six blood factors related to vascular health or damage correlated with the neuroinflammation signal.
“Is it dangerous to keep getting COVID-19?”
An emphatic exception to @ianbetteridge’s Law:
YES.
People seem slowly starting to realise that #ItsNotJustACold and repeated #Covid infections make developing #LongCovid ever more likely.
‘The growing consensus on multiple infections is therefore that “each time you get hit, it does impact your body, so let’s try not to get it too many times,” says Smith.’
“Zero times” would be ideal. “No more times” is next best.
“Compared to uninfected people, [people who caught Covid-19 between March and November 2020 (before vaccines were available) were] around 40% more likely to develop cardiovascular disease and five times more likely to die during the 18 months afterwards. People who had experienced severe infection were at even higher risk.”
“SARS-CoV-2 infection and the brain: direct evidence for brain changes in milder cases”
“Heart disease and stroke are 33% higher than expected, vs. before the pandemic”
More misinformation from Wen:
"I think [the immunity gap] hypothesis explains the higher-than-usual rates of hospitalization because of the respiratory syncytial virus (RSV) last winter. It’s also possible that some people who have only recently relaxed precautions are “catching up” and getting more illnesses now.”
(https://apple.news/AGm4FCVmRTMuGxg_eBwk_mA)
No.
It's because — due to COVID-minimisers (like Wen) — many have a weakened immune system:
https://globalnews.ca/news/9272293/immunity-debt-covid-19-misinformation/
@DenisCOVIDinfoguy @auscovid19
It’ll be “interesting" to compare 2024…
Related:
“California’s health department has changed its COVID-19 guidance … The new recommendations, issued last week, reflect a more relaxed approach to isolation and testing, allowing people who test positive for COVID-19 but do not have symptoms to return to work and school.”
California’s health department has changed its COVID-19 guidance, which could have significant implications for people of all ages statewide. The new recommendations, issued last week, reflect a more relaxed approach to isolation and testing, allowing people who test positive for COVID-19 but do not have symptoms to return to work and school.
“California’s health department has changed its COVID-19 guidance … The new recommendations, issued last week, reflect a more relaxed approach to isolation and testing, allowing people who test positive for COVID-19 but do not have symptoms to return to work and school.”
I need a new emoji to convey my reaction to this.
Something like, <WTAF intensifies>.
California’s health department has changed its COVID-19 guidance, which could have significant implications for people of all ages statewide. The new recommendations, issued last week, reflect a more relaxed approach to isolation and testing, allowing people who test positive for COVID-19 but do not have symptoms to return to work and school.
Eleanor Rees
mmalc
