"Our understanding of thymic blood vascular hemodynamics is limited due to technical challenges associated with accessing the native thymus in live mice. To overcome this challenge, we developed an intravital two-photon imaging method to visualize the native thymus in vivo and investigated functional changes to the vascular system following sublethal irradiation."
#Preprint
#Immunology #TwoPhoton #Intravital
https://www.biorxiv.org/content/10.1101/2023.04.10.536267v1?med=mas
What if we could study #cancer progression and #metastasis in vivo, in real time, and at single-cell resolution?
David Entenberg, Maja Oktay, and John Condeelis at Albert Einstein College of Medicine summarize the current state of the art of #intravital #imaging, present some of the challenges that remain in the field, how to address them, and future perspectives.
Article in Nature Reviews Cancer: https://www.nature.com/articles/s41568-022-00527-5
This Review covers recent advances in intravital imaging of mammalian models of cancer and describes how intravital imaging can help to understand the role of the tumour microenvironment in cancer progression and metastasis, and to develop novel treatments and therapies.
Thiago Carvalho
Christian Tidona