HLH Detroit Halle - Tenebrae
17. April 2025, 19:00:00 CEST - GMT+2 - Helmut-List-Halle, 8020, Graz, Österreichhttps://events.graz.social/events/1e1b242c-71a4-45ee-8878-f0e6851b0b3a
17.04.2025, 19:00:00 - GMT+2 - Helmut-List-Halle, 8020, Graz, Österreich - Tenebrae 17. April @ 19:00 - 20:15 Fantastisches Stimmenprogramm mit dem Ensemble The Gesualdo Six Ausgehend von Carlo Gesualdos packenden Responsorien für die Nächte der Karwoche taucht uns das brit…
HLH Detroit Halle - Stabat Mater
18. April 2025, 19:00:00 CEST - GMT+2 - Helmut-List-Halle, 8020, Graz, Österreichhttps://events.graz.social/events/c3ebac73-b38a-41a9-b542-7d0c042b98b4
18.04.2025, 19:00:00 - GMT+2 - Helmut-List-Halle, 8020, Graz, Österreich - Stabat Mater 18. April @ 19:00 - 20:15 Herzzerreissendes zum Karfreitag Pergolesis ergreifendes Stabat Mater und Karfreitagsmusik von Johann Joseph Fux Ein neuer Name unter den männlichen Altisten: De…
HLH Detroit Halle - Halleluja
20. April 2025, 19:00:00 CEST - GMT+2 - Helmut-List-Halle, 8020, Graz, Österreichhttps://events.graz.social/events/16afa627-c50d-44c6-90d0-9a79a75351e0
20.04.2025, 19:00:00 - GMT+2 - Helmut-List-Halle, 8020, Graz, Österreich - Halleluja 20. April @ 19:00 - 20:15 Kristina Miller Auf eine ausgelassene Tastenreiseentführt uns Pianistin Kristina Miller mit ihren Klavierpartnern und mit vier bis sechs Händen. Um Händels „Halle…
HLH Detroit Halle - Maskenball im Gänsestall
21. April 2025, 19:00:00 CEST - GMT+2 - Helmut-List-Halle, 8020, Graz, Österreichhttps://events.graz.social/events/a06534ee-47e5-4a80-94e2-e8601ce887cf
21.04.2025, 19:00:00 - GMT+2 - Helmut-List-Halle, 8020, Graz, Österreich - Maskenball im Gänsestall 21. April @ 19:00 - 20:15 Vokalquintett MGV Walhalla zum Seidlwirt Mit virtuosem Frohsinn widmen sich die globalen Männerstimmen des MGV Walhalla zum Seidlwirt aus Berlin dem…
HLH Detroit Halle - Generate25
23. Mai 2025, 12:00:00 CEST - GMT+2 - Helmut-List-Halle, 8020, Graz, Österreichhttps://events.graz.social/events/7781bf57-e550-4599-9206-7d75a0e8c51a
23.05.2025, 12:00:00 - GMT+2 - Helmut-List-Halle, 8020, Graz, Österreich - GENERATE25 23. Mai @ 12:00 - 24. Mai @ 6:00 Talks, Präsentationen, Workshops & Clubabend Präsentiert von GENspace & Schallware GENERATE25 ist die erste Ausgabe des Playground for Creative Technology,…
I’ve been feeling a lot of grief this weekend after reading about Professor Amit Patel - a nationally recognized doctor & expert in the rare disease HLH - who died in hospital when medical staff refused to acknowledge his expertise in his own condition.
Many disabled and chronically ill individuals know how dangerous hospitals can be - but reading about a doctor (who had a spouse who was also a physician advocating for him) being unable to get the care he needed to stay alive? It’s terrifying.
I wrote about his death, my own experiences with medical trauma and the need for a safer system for all.
https://open.substack.com/pub/disabledginger/p/prof-amit-patel-death?r=19dk2e&utm_medium=ios
#Disability #ChronicIllness #RareDisease #Spoonies #Ableism #gaslighting #HLH #MedicalTrauma #MedicalGaslighting #Discrimination #DisabilityRights #CovidIsNotOver #CovidCaution
Interested in TB? Interested in HLH?
Then check out our systematic review & meta-analysis on TB-associated cases of HLH.
Fab collaboration BETWEEN clinical research teams at UCL & @Radboud_uni
#medicine #infectiousdiseases #IDMastodon #HLH #inflammation #TB #tuberculosis
So what did we find?🧵👇
Background Tuberculosis (TB) can induce secondary hemophagocytic lymphohistiocytosis (HLH), a severe inflammatory syndrome with high mortality. To improve insight into optimal diagnostic and treatment strategies, we integrated all published reports of adult HIV-negative TB-associated HLH (TB-HLH) globally to define clinical characteristics and therapeutic approaches associated with improved survival. Methods PubMed, Embase, and Global Index Medicus were searched for eligible records. TB-HLH cases were categorized into patients with a confirmed TB diagnosis receiving antituberculosis treatment while developing HLH, and patients presenting with HLH of unknown cause later diagnosed with TB. We integrated patients' clinical characteristics, diagnostic test results, and pre-specified parameters associated with survival into a logistic regression model. Results We identified 115 individually reported cases, 45 (39.1%) from low TB incidence countries (<10/100.000 per year). Compared to HLH patients with known TB (n=21), patients with HLH of unknown cause (n=94), more often had extrapulmonary TB (88.3% vs. 66.7%), while the opposite was true for pulmonary disease (59.6% vs. 91.5%). Overall, Mycobacterium tuberculosis was identified in the bone marrow in 78.4% of patients for whom examination was reported (n=74). Only 10.5% (4/38) of patients tested had a positive tuberculin skin test or interferon gamma release assay. In-hospital survival was 71.9% (69/96) in those treated for TB and 0% (18/18) in those who did not receive antituberculosis treatment (p < 0.001). Conclusions Tuberculosis should be considered as a cause of unexplained HLH. TB-HLH is probably under-reported, and the diagnostic work-up of HLH patients should include bone marrow examination for evidence of M. tuberculosis infection. Prompt initiation of antituberculosis treatment will likely improve survival. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement GP time was funded by the UCLH NIHR Biomedical Research Centre. AvL was supported by a Clinical Fellowship of The Netherlands Organization for Health Research and Development - ZonMw, 9032212110006 ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: All data used for this systematic review and meta-analysis were derived from openly available, published case reports and series. We defined and followed a pre-specified search strategy according to PRISMA guidelines that was registered with the international prospective register of systematic reviews (PROSPERO, CRD42022349077). The studies that were included in our analyses, and references to their corresponding primary publications, are provided in the supplementary file. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data produced in the present work are contained in the manuscript.
Some evidence of a genetic predisposition for hyperinflammation to convert to HLH
#IDMastodon #MedMastodon #immunology #infectiousdisease #HLH #HIV #IRIS #medicine
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