~60% of germ cells in
#Celegans hermaphrodites are eliminated in meiotic prophase to maintain tissue homeostasis, but how? This study shows that size of meiotic
#GermCells is reduced by apical
#actomyosin constriction, leading to
#apoptosis #PLOSBiology https://plos.io/4g4hpTE
Actomyosin-mediated apical constriction promotes physiological germ cell death in C. elegans
Germ cell apoptosis in C. elegans hermaphrodites eliminates around 60% of all cells in meiotic prophase to maintain tissue homeostasis. Here, the authors show that the size of meiotic germ cells is reduced by apical actomyosin constriction, which causes cell death to maintain homeostasis in C. elegans germline.
RNA/protein condensates called "germ granules" are ubiquitous among animal
#GermCells. @gavislab shows that
#Drosophila #GermGranules initially protect RNAs but then become sites of selective mRNA degradation, supporting germ cell development
#PLOSBiology https://plos.io/3UxHmR7
Plasticity of Drosophila germ granules during germ cell development
Condensates of RNAs and proteins called "germ granules" are ubiquitous among animal germ cells. This study shows that Drosophila germ granules, which initially protect RNAs, subsequently become sites of selective mRNA degradation; this plasticity supports germ cell development.
RNA/protein condensates called "germ granules" are ubiquitous among animal
#GermCells. @gavislab shows that
#Drosophila #GermGranules initially protect RNAs but then become sites of selective mRNA degradation, supporting germ cell development
#PLOSBiology https://plos.io/3UxHmR7Plasticity of Drosophila germ granules during germ cell development
Condensates of RNAs and proteins called "germ granules" are ubiquitous among animal germ cells. This study shows that Drosophila germ granules, which initially protect RNAs, subsequently become sites of selective mRNA degradation; this plasticity supports germ cell development.
RNA/protein condensates called "germ granules" are ubiquitous among animal
#GermCells. @gavislab shows that
#Drosophila #GermGranules initially protect RNAs but then become sites of selective mRNA degradation, supporting germ cell development
#PLOSBiology https://plos.io/3UxHmR7Plasticity of Drosophila germ granules during germ cell development
Condensates of RNAs and proteins called "germ granules" are ubiquitous among animal germ cells. This study shows that Drosophila germ granules, which initially protect RNAs, subsequently become sites of selective mRNA degradation; this plasticity supports germ cell development.
Developmental genetics: How germ cells cut the cord from their parents
For the first cell to develop into an entire organism, genes, RNA molecules and proteins have to work together in a complex way. At first, this process is indirectly controlled by the mother. At a certain point in time, the protein GRIF-1 ensures that the offspring cut themselves off from this influence and start their own course of development. A research team from Martin Luther University Halle-Wittenberg (MLU) details how this process works in the journal Science Advances.
Glad and relieved to share on mastodon my first co-first work from one of my PhD projects with Eric Miska & Azim Surani. ☺️ Hope it’s a useful one: we team with Giorgia Battsitoni and Greg Hannon to investigate a prior observation of piRNAs in mPGCs in vitro.
Alas, we do not detect piRNAs in Day 6 mPGCLCs.
https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00783-3 #piRNAs #GermCells #mPGC #mPGCLC #DevCell #MattersArisingConservation of oocyte development in germline cysts from Drosophila to mouse
https://doi.org/10.7554/elife.83230 #oocyte #germline #germcells
Conservation of oocyte development in germline cysts from Drosophila to mouse
Early oocyte development takes place in germline cysts and is strikingly conserved from Drosophila to mouse, reflecting common mechanisms that may help reverse aging and specify oocyte and early embryo polarity.
PLOS Biology
Phys.org
Navin B Ramakrishna
Martinho lab