Interesting paper from Tatjana Trcek lab.
She & her team looked at fly #GermGranules nucleation and, well... the title says it all:
"Proteins rather than mRNAs regulate nucleation and persistence of Oskar germ granules in Drosophila "
#mRNA #mRNALocalization #Drosophila #LLPS
It is also her 1st paper as #NewPI so congrats are in order.
https://www.sciencedirect.com/science/article/pii/S2211124723007349
A very nice review on RNA granules from Geraldine Seydoux's lab at Genes & Development.
"RNA granules: functional compartments or incidental condensates?"
#RNA #granules #mRNA #phaseseparation #translation #splicing #Pbodies #StressGranules
#GermGranules
Condensates of RNAs and proteins called "germ granules" are ubiquitous among animal germ cells. This study shows that Drosophila germ granules, which initially protect RNAs, subsequently become sites of selective mRNA degradation; this plasticity supports germ cell development.
Condensates of RNAs and proteins called "germ granules" are ubiquitous among animal germ cells. This study shows that Drosophila germ granules, which initially protect RNAs, subsequently become sites of selective mRNA degradation; this plasticity supports germ cell development.
Condensates of RNAs and proteins called "germ granules" are ubiquitous among animal germ cells. This study shows that Drosophila germ granules, which initially protect RNAs, subsequently become sites of selective mRNA degradation; this plasticity supports germ cell development.
Gal Haimovich ๐ท๐ฌโฃ๐ณ๏ธโ๐๐ณ๏ธโโง
PLOS Biology