I went to sit by the sea tonight, trying to find some peace. Someone was playing some godawful ‘music’ so I left and drove a couple of miles up the coast. I needn’t have bothered. Same problem.
Why do people think it’s fine to inflict their choices on others?
Gah!
How I feel by the time Friday rolls around, ha. Happy Friday!
What The Heck, available here: https://1-lisas-baker.pixels.com/featured/what-the-heck-lisa-s-baker.html
#cat #cats #catlover #catlovers #catsofmastodon #mastocats #art #arte #artwork #wallart #homedecor #buyintoart #wallartforsale #homedecorideas #artforsale #mastoart #mastodonart #fediart #fediverse #canvasprints #artprints #cute #fun #frazzled #dazedandconfused #illustration #drawing #mixedmedia #funny
Don't know about you lovely lot, but it's definitely been one of those....weeks when the world would indeed be a calmer and quieter place if I had been born with the überly useful powers to instantly mince someone into an amorphous pile of steaming mush...just by smiling at them.
So, on this first day of February, I shall try to be my best self until that time arrives and I finally snap and become the human embodiment of Kali whilst mincing all asunder.
Morphogenetic gradients specify distinct cell populations within tissues. Originally, morphogens were conceived as substances that act on a static field of cells, yet cells usually move during development. Thus, the way cell fates are defined in moving cells remains a significant and largely unsolved problem. Here, we investigated this issue using spatial referencing of cells and 3D spatial statistics in the Drosophila blastoderm to reveal how cell density responds to morphogenetic activity. We show that the morphogen decapentaplegic (DPP) attracts cells towards its peak levels in the dorsal midline, whereas dorsal (DL) stalls them ventrally. We identified frazzled and GUK-holder as the downstream effectors regulated by these morphogens that constrict cells and provide the mechanical force necessary to draw cells dorsally. Surprisingly, GUKH and FRA modulate the DL and DPP gradient levels and this regulation creates a very precise mechanism of coordinating cell movement and fate specification.
Morphogenetic gradients specify distinct cell populations within tissues. Originally, morphogens were conceived as substances that act on a static field of cells, yet cells usually move during development. Thus, the way cell fates are defined in moving cells remains a significant and largely unsolved problem. Here, we investigated this issue using spatial referencing of cells and 3D spatial statistics in the Drosophila blastoderm to reveal how cell density responds to morphogenetic activity. We show that the morphogen decapentaplegic (DPP) attracts cells towards its peak levels in the dorsal midline, whereas dorsal (DL) stalls them ventrally. We identified frazzled and GUK-holder as the downstream effectors regulated by these morphogens that constrict cells and provide the mechanical force necessary to draw cells dorsally. Surprisingly, GUKH and FRA modulate the DL and DPP gradient levels and this regulation creates a very precise mechanism of coordinating cell movement and fate specification.
Morphogenetic gradients specify distinct cell populations within tissues. Originally, morphogens were conceived as substances that act on a static field of cells, yet cells usually move during development. Thus, the way cell fates are defined in moving cells remains a significant and largely unsolved problem. Here, we investigated this issue using spatial referencing of cells and 3D spatial statistics in the Drosophila blastoderm to reveal how cell density responds to morphogenetic activity. We show that the morphogen decapentaplegic (DPP) attracts cells towards its peak levels in the dorsal midline, whereas dorsal (DL) stalls them ventrally. We identified frazzled and GUK-holder as the downstream effectors regulated by these morphogens that constrict cells and provide the mechanical force necessary to draw cells dorsally. Surprisingly, GUKH and FRA modulate the DL and DPP gradient levels and this regulation creates a very precise mechanism of coordinating cell movement and fate specification.
Beverley
Code of Amor 💘
Lisa S Baker Art
Jon Bowie
Mike In The Garden 🏴🇮🇪
Lou
Chris Pitts
PLOS Biology