While CRISPR is an amazing biological system, it is far from the only one. Among the dozens that have since been identified in bacteria, what about other organisms?
MIT and Harvard scientists have described the first such RNA-guided programmable system in eukaryotes based on the protein Fanzor.
Its compact complexity may make it more suitable for use in humans and other eukaryotes.
#CRISPR #RNA #Fanzor #Biology #Biotech #Biotechnology #Science #Scicomm
This #xkcd needs up update for #fanzor https://www.nature.com/articles/s41586-023-06356-2
Researchers uncover a new CRISPR-like system in animals that can edit the human genome
A team of researchers led by Feng Zhang at the McGovern Institute for Brain Research at MIT and the Broad Institute of MIT and Harvard has uncovered the first #programmable #RNA-#guided system in #eukaryotes — organisms that include fungi, plants, and animals.
In a study published today in Nature, the team describes how the system is based on a protein called #Fanzor. They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells.
The #compact Fanzor systems have the potential to be more easily delivered to cells and tissues as therapeutics than #CRISPR-#Cas systems, and further refinements to improve their targeting efficiency could make them a valuable new technology for human #genome #editing
https://news.mit.edu/2023/fanzor-system-in-animals-can-edit-human-genome-0628
Researchers have discovered the first programmable RNA-guided system discovered in eukaryotes. The technology, known as Fanzor, has the potential to be more easily delivered to cells and tissues than CRISPR-Cas systems, and further refinements could make them a valuable new technology for human genome editing.
Researchers uncover new #CRISPR-like system in #animals that can edit the human #genome.
https://phys.org/news/2023-06-uncover-crispr-like-animals-human-genome.html
A team of researchers led by Feng Zhang at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has uncovered the first programmable RNA-guided system in eukaryotes—organisms that include fungi, plants, and animals.
Sterling Ericsson
ℵ₀ 🏳️⚧️🏴☠️
Darren
Jason Yip
ISOGG
Chuck Darwin
CellBioNews