πŸ” For #ECPR as for all patients keep on caring & keep on analyzing! Initial lactate can indicate higher burden of ischemia prior to #ECMO, with subsequent clearance determined by relationship between lactate catabolism vs generation. Neurologic survival advantage if adequate #extracorporeal BF/catabolic function & no longer ischemia. Pts who fail to rapidly clear lactate warrant evaluation for: ongoing ischemia or insufficient #ECLS
πŸ–‡οΈ https://bit.ly/3KGs2xo

Refers to
πŸ”“ https://bit.ly/3x997bt

Prolonged VV #ECMO for #ARDS in adults, analysis of ELSO - Extracorporeal Life Support Organization Registry:
πŸ” >13 K patients included, 2012-2022
⏳ prolonged #extracorporeal support increased & accounts for substantial portion of cases
🫁 among pts that survive for at least 21 days, run duration is not predictive of survival to hospital discharge
Subjectively withdrawing care due to run duration should be reconsidered.
πŸ”“ https://bit.ly/4aYCACt

With editorial
πŸ”“ https://bit.ly/3VhWhQ7

What is happening in this 44-year-old man on VA #ECMO??
🚨 #ECPR after 30 min of refractory cardiac arrest post-myocardial infarction
πŸ«€ recovered native cardiac activity but severe postresuscitation vasoplegia leading to important fluid filling to maintain #extracorporeal blood flow
πŸ–₯️ TEE showed right atrial collapse
…. cardiac tamponade?? Collapse reversed within seconds during a transient reduction in EBF
Free to read #FOAMcc #FOAMecmo on @ICM
πŸ”“ https://rdcu.be/dJW8S
Right atrial collapse mimicking cardiac tamponade in a patient on veno-arterial extracorporeal membrane oxygenation

πŸš‘ 🚁 Prehospital ground & helicopter-based #ECPR reduce barriers to #extracorporeal support, potentially improving #OHCA survival rates! Geographic Information System model to estimate transport times & number of #ECLS eligible patients within the United States. The study demonstrates a 2-fold increase in #ECMO eligibility for field-deployable ground-based system + 4-fold increase for HEMS-based system vs to current hospital-based system.
πŸ–‡οΈ https://bit.ly/4bEE0TK
Mechanical ventilation during #ECMO support, new trends & continuing challenges
🫁 evolving concepts of lung protective ventilation and #extracorporeal gas exchange
current clinical practice
MV in the EOLIA trial
recommended MV settings
prone positioning
neuromuscular blocking agents
πŸ«πŸ«€ MV in #ECLS for cardiac support
Open access #FOAMcc #FOAMecmo
πŸ”“ https://bit.ly/3WJWkGu
From the #EuroELSO2024 Perfusion special issue
πŸ”“ journals.sagepub.com/toc/prfa/39/1_suppl
Cardiogenic shock in 2024:
πŸ«€ #extracorporeal life support #ECLS
πŸ«€ left ventricular unloading strategies in #ECMO
strategies & evidence from recent trials (& beyond)
Free to read #FOAMcc #FOAMecmo on @ICM
πŸ”“ https://rdcu.be/dHzLz
Cardiogenic shock in 2024: insight the complex reality of ECLS and left ventricular unloading strategies

#Extracorporeal versus conventional #CPR in out-of-hospital & in-hospital cardiac arrest, updated meta-analysis & trial sequential analysis (2000-Oct 2023, 13 RCTs/PSMs included):
πŸ«€ #ECLS significantly reduces in-hospital mortality, improving 30-day survival & neurological outcome
πŸ«€ recent studies revealed newly significant decrease in mortality in #OHCA
Open access #FOAMcc #FOAMecmo
πŸ”“ https://rdcu.be/dzmpV
Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: an updated meta-analysis and trial sequential analysis | Critical Care

Switching from VV to VPA #ECMO in patients with severe respiratory failure experiencing refractory hypoxemia: decreasing recirculation &
improving systemic DO2?? In this experience:
🫁 PaO2 increased with reduced #extracorporeal blood flow
πŸ’‰ decreased need for deep sedation
πŸ«€lower requirement for inotropic support
πŸ“‰ low frequency of associated complications
πŸ“ˆ survival to hospital discharge
of 54%, but longer runs compared to previously reported.
ASAIO Journal
πŸ–‡οΈ https://bit.ly/48JKeR5
Venopulmonary Artery Extracorporeal Life Support (VPa... : ASAIO Journal

CMO to a configuration that returns the flow to pulmonary artery, such as venopulmonary extracorporeal membrane oxygenation (VPa ECMO) may decrease recirculation and improve systemic oxygen delivery. We present a retrospective report that describes the impact of VPa ECMO on oxygenation during sedation withdrawal in 41 patients who received VV ECMO for coronavirus disease 2019 (COVID-19). We evidenced that arterial oxygen pressure (PaO2) increased from 68 to 112.3 mm Hg (p = 0.001) with a reduction of ECMO flow (5.7–4.8 L/m; p = 0.001). Other findings included lower rates of depth sedation (Richmond Agitation Sedation Scale [RASS] ≀3, 37–63%; p = 0.007) and lower requirement inotropic support assessed by LVIS score (4.7–1.1; p = 0.005). Discharge survival was 54% with a sustained benefit until day 79. This cannulation strategy improved effectively PaO2 in this cohort, it may be an alternative in patients with RH in VV ECMO....

LWW
Use of #POCUS in neonatal
& pediatric #ECLS:
πŸ–₯️ pre #ECMO assessment: heart & lung function, indication and contraindications for initiation
πŸ–₯️ cannulation for different VA & VV configurations
πŸ–₯️ monitoring during #extracorporeal support: cardiac function, lung aeration & recruitment
πŸ–₯️ detection and troubleshooting
of complications: cardio‑vascular, respiratory, neurological
πŸ–₯️ weaning
Free to read #FOAMcc #FOAMus #FOAMecmo #echofirst #PedsICU
πŸ”“ https://rdcu.be/dwx2a
Use of point-of-care ultrasound (POCUS) to monitor neonatal and pediatric extracorporeal life support

βš–οΈ Racial discrepancy in detecting hypoxemia in VV #ECMO, ELSO - Extracorporeal Life Support Organization Registry analysis demonstrating that Hispanic & Black VV #ECLS patients experienced occult hypoxemia more than White patients.
⚠️ Carefully monitor SaO2 during ECMO support in these patients, especially if high #extracorporeal blood flow & lactates, due to the risk for occult hypoxemia.
Open access preprint #FOAMcc #FOAMecmo
πŸ”“ https://bit.ly/3RiLUdT
Characterizing the Racial Discrepancy in Hypoxemia Detection in VV-ECMO: An ELSO Registry Analysis

Importance: Skin pigmentation influences peripheral oxygen saturation (SpO2) measured by pulse oximetry compared to the arterial saturation of oxygen (SaO2) measured via arterial blood gas analysis. However, data on SpO2-SaO2 discrepancy are ...